An interventional study of Resistance Training with Cardio and Resistance Training with Conditioning in Cancer and Breast Cancer, sponsored by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute). Recruiting at 1 site in United States. Open to female participants aged 20 Years to 89 Years. Per ClinicalTrials.gov, last updated 2026-08-17.
Sponsored by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Not applicable, Interventional, and Other
In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer.
14,825 studies on the registry are indexed under Breast Neoplasms; 3,319 are open to participants now.
This study's planned enrollment of 40 is below the median of 72 across 10,896 interventional studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) is the lead sponsor of 49 studies on the registry; 20 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 4 (44%) have results posted.
Compared within Breast Neoplasms, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Neoplasms. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: Resistance Training with Cardio
Behavioral: Resistance Training with Conditioning
Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to steady-state cardiovascular exercise. The cardio day will utilize ergometer-based exercises (rowing ergometer, Assault Air Bike) and unweighted sled pushes, with each activity lasting 10 minutes continuously. The overall program aims to improve cardiorespiratory fitness and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).
Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to high-intensity conditioning. The conditioning day involves a circuit format of 6 total exercises, completed for 8 repetitions each across 8 sets, with limited rest periods (10 seconds or less) between exercises and sets. Exercise selection is total-body focused, alternating between upper and lower body movements. The program aims to improve muscular conditioning and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).
Change in Muscle Mass
Measured as total muscle mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for muscle tissue thickness.
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Change in Fat Mass
Measured as total fat mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for adipose tissue thickness.
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Change in Blood Pressure
Pre-workout blood pressure (systolic and diastolic) measurements.
Time frame: Baseline (Prior to Program), at Month 1, and At Exercise Program Completion (approximately 2 months).
Change in Resting Metabolic Rate
Resting metabolic rate (RMR) at the completion of the exercise regimen.
Time frame: At Exercise Program Completion (approximately 2 months).
Change in Body Composition Metrics (Other than Muscle/Fat Mass)
Includes body mass, % fat, and % fat-free mass, measured via InBody 970 bioimpedance analysis.
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Change in Phase Angle
Phase angle, determined via InBody 970 bioimpedance analysis.
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Exercise Adherence
Defined as the number of sessions attended out of total sessions, as recorded by attendance logs.
Time frame: Throughout the Exercise Program (approximately 2 months).
Change in Grip Strength
Grip strength assessed via Jamar Hand Dynamometer bilaterally (three consecutive measures per hand).
Time frame: Baseline (Prior to Program), During Exercise Program (before and after each workout), and At Exercise Program Completion (approximately 2 months).
Started Jul 2026 (actual). Primary completion is estimated for Apr 2027, 9 months after the start.
Of 2,661 non-industry interventional studies with no phase under Breast Neoplasms, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 66. This study's planned 9 months is below that.
Counting every sponsor, half of 2,771 studies reached it within 33 months; a quarter within 15 and three quarters within 66.
How these figures are worked out, and which studies are left out of them.
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Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)