An interventional study of Irrigation of Triamcinolone and Hypertonic Saline 10% in Seroma Formation, sponsored by Cairo University. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-07-29.
Sponsored by Cairo University · Not applicable, Interventional, and Prevention
A total of 90 abdominoplasty patients were randomly assigned into three groups:
Group A: Triamcinolone group, Group B: Hypertonic saline group, Group C: Control group
Randomization:
It was performed using the closed envelope technique.
Technique:
After performing a Lipo-abdominoplasty Group A (triamcinolone) irrigates 10 cm saline mixed with two 40 mg vials through the umbilicus into dead space; Group B (hypertonic saline) irrigates 20 cm of 10% solution similarly; Group C (control) receives no irrigation
A total of 90 patients were recruited in this study from November 2023 until July 2025. These patients presented to the outpatient clinic of the Plastic and Reconstructive Surgery Department, Kasr Al ainy Hospital with pendulous abdomen or manifestations of myofascial abdominal laxity and weakness or more commonly, a combination of both. In additions, almost all patients were complaining of localized stubborn fat deposits usually in the flank and epigastric areas that also needed to be addressed.
Randomization:
It was performed using . Opaque, sealed and sequentially numbered envelopes containing group assignments were prepared by an independent participant not enrolled in the study. Each envelope was opened only after a participant enrollment, ensuring allocation concealment and preventing selection bias.
Pre-operative: Before admission, patients were consented on the study methodology and the randomization process. The initial consultation of our patients revolved around the expected procedural details, the preoperative preparatory steps and the post-operative recovery time and details. Afterwards, proper history and examination were conducted along with routine preoperative labs and abdominal ultrasound to detect hernial defects.
Preoperative markings: In the standing position, after proper exposure of the trunk area, Markings of the liposuction area over the back were done. Followed by anterior markings which begins with identifying the anterior midline and marking both linae semilunaris while the patient contracts the rectus abdominis muscles. Next, the lateral ends of the expected abdominal scars are marked at the abdominal fold with the patient flexing the trunk 30 degrees. The midpoint of the proposed incision site is then marked in the midline at 6-8 cm under medium stretch, confirmed at 8-10 cm under maximum stretch. Measurements of 7 cm lateral to the midline at this site and 9 cm from the midline above the umbilicus are taken, ensuring these points coincide during closure for 2 cm abdominal flap medialization. This midpoint connects laterally to the 7 cm marking and then to the proposed incision ends. Using a pinch test, the proposed upper incision is marked in the midline above the umbilicus and connected to the lateral ends of the proposed lower incision. Finally, areas for liposuction in the anterior flanks and epigastrium are marked.
Operative details: The patient is placed prone, sterilized, draped, and positioned in jack-knife for initial preparation, receiving one dose of a 3rd generation cephalosporin. Super wet solution (1 mg adrenaline, 1 mg tranexamic acid, and 10 cc of 2% lidocaine per 500 ml normal saline) is infiltrated via sacral and bra-line access incisions, followed by a 15-minute wait, then liposuction in marked areas using a straight Mercedes-shaped blunt-tipped 4 mm cannula until a desirable pinch is achieved. The patient is turned supine with trunk extension at the hips, re-sterilized, draped, and anterior access incisions made for infiltrating the same super wet solution into flanks and epigastrium, awaiting 15 minutes before liposuction to desirable pinch endpoint. The proposed incision site opens slantingly to preserve fat over anterior superior iliac spines, followed by uniform supra-fascial dissection to the umbilicus; the umbilicus is incised superficially, dissected to the anterior rectus sheath, circled to free its stalk, and a narrow epigastric tunnel elevated supra-fascial along medial rectus borders per Saldanha's technique without wider undermining. Plication of divarication occurs in two layers above and below the umbilicus with PDS 1-0 loop and proline 1-0 if indicated. The patient flexes to 45 degrees for flap excision, with two suction drains placed laterally; the neo-umbilicus is incised appropriately, umbilicus brought up, and closure performed in layers using 0 Vicryl for Scarpa's fascia, 2-0 Vicryl sub-dermally, and 3-0 Monocryl sub-cuticular. Drains are closed, then per group: Group A (triamcinolone) ; Group B (hypertonic saline) ; Group C (control). Doses were used according to best available evidence. The umbilicus secures with 4-0 Vicryl interrupted dermal and 4-0 Monocryl subcuticular skin sutures. A compression garment with underlying foam support are applied immediately
Post-operative sequalae: The patient is transported to the ward in a semi-sitting position and maintained this way until discharge. Drains remain closed for 1 hour postoperatively, then fluid amount and color (categorized as dark red, serosanguineous, or serous) are measured and documented every 12 hours until removal, with patients instructed pre-discharge on consistent drainage collection and measurement, documenting every 12 hours themselves. Early ambulation with regular fluid intake prevents VTE, and chemoprophylaxis starts if indicated per the 2005 Caprini score. The first dressing occurs the next day to detect early liposuction complications, followed by discharge on antibiotics and analgesics. Lymphatic massage begins as early as postoperative day 3.
In cases of seroma: Clinical seromas, diagnosed by palpable bulge or swelling, are addressed and aspirated using a wide bore cannula and 20 cc syringe. The amount of aspirated fluid is documented per session. And the sessions are repeated every 3 to 4 days according to the patient's condition till the seroma is resolved.
101 studies on the registry are indexed under Seroma; 22 are open to participants now.
This study's enrollment of 90 is close to the median of 100 across 92 interventional studies indexed under Seroma.
Browse Seroma studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Irrigation of Triamcinolone post lipo-abdominoplasty 10cc normal saline 0.9% with 80mg of Triamcinolone
Drug: Irrigation of Triamcinolone
Irrigation of Hypertonic Saline post lipo-abdominoplasty 20cc of 10% Hypertonic Saline
Drug: Hypertonic Saline 10%
Lipo-Abdominoplasty
Drug: Control
Irrigation of Triamcinolone 80 mg post abdominoplasty to decrease the incidence of seroma and allow early drain removal
Irrigation of Hypertonic saline 10%
Control Group with no irrigation
number of abdominoplasty patients having seroma after intraoperative Triamcinolone irrigation
number of patients having seroma after irrigation of 10 cc of saline 0.9% mixed with 80 mg triamcinolone
Time frame: 8 weeks
number of abdominoplasty patients having seroma after intraoperative hypertonic saline irrigation
number of patients having seroma after irrigation of 20cc of 10% hypertonic saline
Time frame: 8 weeks
days needed to remove the drain post abdominoplasty after intraoperative triamcinolone irrigation
drains are removed when the amount in 24 hours is less than 50 cc
Time frame: up to 15 days
Days needed to remove the drain post abdominoplasty after intraoperative Hypertonic saline irrigation
drains are removed when the amount in 24 hours is less than 50 cc
Time frame: Up to 15 days
total amount of seroma, measured in cc, in patients who develop seroma after intraoperative Triamcinolone irrigation following abdominoplasty
amount is aspirated by a syringe and documented each session of aspiration
Time frame: 8 weeks
total amount of seroma, measured in cc, in patients who develop seroma after intraoperative hypertonic saline irrigation following abdominoplasty
amount is aspirated by a syringe and documented each session of aspiration
Time frame: 8 weeks
total drain output, measured in cc, post abdominoplasty after intraoperative triamcinolone irrigation
drains are monitored and emptied every 12 hours and the amount is documented
Time frame: up to 15 days
total drain output, measured in cc, post abdominoplasty after intraoperative hypertonic saline irrigation
drains are monitored and emptied every 12 hours and the amount is documented
Time frame: up to 15 days
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No — We dont have plans on sharing it at the time being yet if it is needed for authentication of data we will are gladly willing to share it
Ran from Nov 2023 to primary completion in Jul 2025, 20 months.
Of 43 non-industry interventional studies with no phase under Seroma, half reached primary completion within 34 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 65. This study's 20 months is below that.
Counting every sponsor, half of 44 studies reached it within 34 months; a quarter within 17 and three quarters within 65.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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