An interventional study of Control Group T0 and Intervention Group T1 in Nephrolithiasis and Calcium Oxalate Kidney Stones, sponsored by University of Lahore. Completed at 1 site in Pakistan. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-07-20.
Sponsored by University of Lahore · Not applicable, Interventional, and Supportive care
Nephrolithiasis is a condition characterized by the formation of crystalline stones in the urinary system. The most common component of these stones is calcium oxalate. The current study was proposed to explore the effect of different concentration of vitamin E supplementation on Calcium oxalate crystal among nephrolithiatic patients.
A randomized controlled trial (pre-post treatment) was conducted on 48 participants who met the inclusion criteria. The participants were selected from the OPD of Hussain Memorial Hospital in Lahore. They were divided into three groups, with each group consisting of 16 participants. The control group (T0) did not receive any treatment, while the treatment groups received different doses of Vitamin E supplementation. The first treatment group (T1) received 200mg of Vitamin E supplementation, and the second treatment group (T2) received 400mg of Vitamin E supplementation, both for a duration of 8 weeks. Data was collected at baseline and after the 8th week of the study, including blood samples for renal function tests (RFT), ultrasounds, and 24-hour urine samples for calcium and oxalate analysis.
460 studies on the registry are indexed under Nephrolithiasis; 108 are open to participants now.
This study's enrollment of 48 is below the median of 92 across 361 interventional studies indexed under Nephrolithiasis.
Browse Nephrolithiasis studies →University of Lahore is the lead sponsor of 223 studies on the registry; 40 are open to participants now.
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Exclusion Criteria:
The control group (T0) did not receive any additional treatment except routine medications
Drug: Control Group T0
T1 group participants were taking 200mg/day of Vitamin E along with conventional medicines
Dietary Supplement: Intervention Group T1
T2 group participants were taking 400mg/day of Vitamin E along with conventional medicines
Dietary Supplement: Intervention Group T2
The participants were on conventional medicines
T1 group participants were taking 200mg/day of Vitamin E supplementation once a day along with conventional medicines
T2 group participants were taking 400mg/day of Vitamin E supplementation once a day along with conventional medicines
Urine Analysis
The laboratory reading of urine analysis involves the identification and microscopic examination of urine to assess the characteristics and concentration of calcium and oxalate crystals present.
Time frame: 8 weeks
Renal function test
This involved measuring the levels of BUN (blood urea nitrogen) and creatinine in the blood.
Time frame: 8 weeks
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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University of Lahore