An interventional study of Experimental Group: Treatment Module D-SUD-M and Control Group in Depression and Substance Use Disorders, sponsored by International Islamic University, Islamabad. Active, not recruiting at 1 site in Pakistan. Open to male participants aged 17 Years to 56 Years. Per ClinicalTrials.gov, last updated 2026-07-16.
Sponsored by International Islamic University, Islamabad · Not applicable, Interventional, and Treatment
The purpose of this study is to evaluate the adaptation and effectiveness of an integrated treatment module, the Depression and Substance Use Disorder Module (D-SUD-M), for male patients experiencing co-occurring depression and substance use disorders in Pakistan.
Participants are divided into two groups: an experimental group receiving the structured D-SUD-M intervention-based sessions and a control group receiving standard routine treatment sessions within the rehabilitation center.
The primary objective is to evaluate whether the specialized intervention module significantly reduces depressive symptoms and substance use severity compared to routine standard care.
A total of 50 male participants aged 17 to 56 years admitted to a rehabilitation facility are enrolled in this parallel-group interventional study.
The research is structured as follows:
8,577 studies on the registry are indexed under Depression; 1,720 are open to participants now.
This study's enrollment of 50 is below the median of 81 across 7,063 interventional studies indexed under Depression.
Browse Depression studies →International Islamic University, Islamabad is the lead sponsor of 10 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this group will recieve special treatment module D-SUD-M for patients with Depression and Substance Abuse.
Behavioral: Experimental Group: Treatment Module D-SUD-M · Behavioral: Control Group
No exposure of special treatment module will be given to the participants of this group.
Behavioral: Control Group
A specialized psychological Intervention based module design for reducing the symptoms and to check the effectiveness of module on patients with depression and substance use disorder. This module is translated and culturally adapted. A manual treatment booklet was written in which eclectic approaches were used like Behaviour therapy, Cognitive behaviour therapy, relapse prevention, group therapy along with activity sheets for each session. 12 intervention based sessions will be given to the participants of this group.
No module based treatment will be given to the participants of this group.
Change in symptoms severity of depression from baseline to post-intervention
Assessed using the Beck Depression Inventory (BDI-II). The BDI-II is a 21-item self-report scale measuring characteristics and symptoms of depression. Total scores range from 0 to 63, with higher scores indicating a worse outcome (greater depressive symptom severity).
Time frame: Baseline to Post-intervention (5months) total weeks(22)
Change in Substance Use Disorder Severity from baseline to post-intervention
Assessed using the Drug Abuse Screening Test (DAST-10). The DAST -10 is a self-report instrument used to evaluate consequences related to drug misuse. Total scores range from 0 to 10, with higher scores indicating a worse outcome (greater severity of substance use-related problems).
Time frame: baseline to post-intervention (5months), total weeks (22)
Started May 2026 (actual). Primary completion is estimated for Sep 2026, 4 months after the start.
Of 3,468 non-industry interventional studies with no phase under Depression, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 41. This study's planned 4 months is below that.
Counting every sponsor, half of 3,566 studies reached it within 21 months; a quarter within 9 and three quarters within 41.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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International Islamic University, Islamabad