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RecruitingNCT07700186Updated Jul 15, 2026

Skin Barrier Function in Women Using UV Nail Lamps

An observational study in Healthy Volunteers, sponsored by University of Split, School of Medicine. Recruiting at 1 site in Croatia. Open to female participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-15.

Sponsored by University of Split, School of Medicine · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
30
Ages
18 Years to 50 Years
Sex
Female
01

Study summary

The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.

The main questions it aims to answer are:

  • Do women who regularly use UV lamps for nail treatments show differences in skin barrier function compared to women who do not use UV lamps?
  • Are transepidermal water loss, skin hydration, and erythema associated with regular exposure to UV lamps used for nail treatments?
  • Does the duration of UV lamp use influence skin barrier function parameters?

Researchers will compare women who regularly use UV lamps during nail treatments with women who have natural nails and do not regularly expose their hands to UV lamps.

Participants will:

  • Attend a single study visit.
  • Complete a short questionnaire regarding nail care habits and duration of UV lamp use.
  • Undergo non-invasive measurements of skin barrier function on the hands, including transepidermal water loss, skin hydration, and erythema assessments.
02

Conditions studied

  • Healthy Volunteers

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Keywords

  • UV nail lamps
  • Gel manicure
  • Skin barrier function
  • Transepidermal water loss (TEWL)
  • Skin hydration
  • Erythema
03

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy adult women recruited from the general population. Participants will be classified into two groups based on their self-reported use of UV nail lamps during nail treatments: regular users of UV nail lamps and women who do not regularly use UV nail lamps and have natural nails.

Inclusion criteria

  • Healthy adult women (≥18 years of age)
  • Willing and able to provide written informed consent
  • Willing to complete the study questionnaire

Exclusion criteria

Exclusion Criteria:

  • Active skin diseases (e.g., psoriasis, vitiligo, or other dermatological conditions)
  • Allergic contact dermatitis
  • Pregnancy or breastfeeding
  • Use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines
04

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
30 participants (estimated)
Patient registry
No

Groups and cohorts

  • Regular UV Nail Lamp Users

    Healthy adult women who regularly undergo nail treatments involving exposure to UV lamps.

  • Non-Users of UV Nail Lamps

    Healthy adult women who do not regularly undergo nail treatments involving exposure to UV lamps and have natural nails.

05

What researchers measure

Primary outcomes

  1. Change in Transepidermal Water Loss (TEWL)

    Skin barrier function will be assessed by measuring transepidermal water loss using a Tewameter TM 300 probe. Values will be expressed in g/m²/h

    Time frame: Day 1 (single study visit)

  2. Change in Skin Hydration

    Hydration of the stratum corneum will be assessed using a Corneometer CM 825 probe.

    Time frame: Day 1 (single study visit)

  3. Change in Skin Erythema

    Skin erythema will be assessed using a Mexameter MX 18 probe.

    Time frame: Day 1 (single study visit)

06

Study locations

1 of 1 sites recruiting
  • University of Split School of Medicine
    Split, 2100, Croatia
    Recruiting
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07700186
Lead sponsor
University of Split, School of Medicine
Responsible party
Sponsor
First posted
Jul 13, 2026
Start date
Jul 2026 (estimated)
Primary completion
Jul 2027 (estimated)
Completion
Jul 2027 (estimated)
Last update
Jul 15, 2026

Study contacts

Josipa Bukić
Contact
jbukic@mefst.hr
+385917933753
Josipa Bukić
principal investigator · University of Split, School of Medicine

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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