ClinicalTrials.gg
CompletedNCT07700186Updated Oct 6, 2026

Skin Barrier Function in Women Using UV Nail Lamps

An observational study in Healthy Volunteers, sponsored by University of Split, School of Medicine. Completed at 1 site in Croatia. Open to female participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-06.

Sponsored by University of Split, School of Medicine · Observational

Updated Oct 6, 2026Now CompletedStart date moved+3 moreGo to Updates ↓
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
40
Ages
18 Years to 50 Years
Sex
Female
01

Study summary

The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.

The main questions it aims to answer are:

  • Do women who regularly use UV lamps for nail treatments show differences in skin barrier function compared to women who do not use UV lamps?
  • Are transepidermal water loss, skin hydration, and erythema associated with regular exposure to UV lamps used for nail treatments?
  • Does the duration of UV lamp use influence skin barrier function parameters?

Researchers will compare women who regularly use UV lamps during nail treatments with women who have natural nails and do not regularly expose their hands to UV lamps.

Participants will:

  • Attend a single study visit.
  • Complete a short questionnaire regarding nail care habits and duration of UV lamp use.
  • Undergo non-invasive measurements of skin barrier function on the hands, including transepidermal water loss, skin hydration, and erythema assessments.
02

Conditions studied

  • Healthy Volunteers

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Keywords

  • UV nail lamps
  • Gel manicure
  • Skin barrier function
  • Transepidermal water loss (TEWL)
  • Skin hydration
  • Erythema
03

In context

Erythema

131 studies on the registry are indexed under Erythema; 17 are open to participants now.

This study's enrollment of 40 is close to the median of 40 across 11 observational studies indexed under Erythema.

Browse Erythema studies →

Lead sponsor

University of Split, School of Medicine is the lead sponsor of 51 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy adult women recruited from the general population. Participants will be classified into two groups based on their self-reported use of UV nail lamps during nail treatments: regular users of UV nail lamps and women who do not regularly use UV nail lamps and have natural nails.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy adult women (≥18 years of age)
  • Willing and able to provide written
  • Willing to complete the study questionnaire

Exclusion criteria

Exclusion Criteria:

  • Active skin diseases (e.g., psoriasis, vitiligo, or other dermatological conditions)
  • Allergic contact dermatitis
  • Pregnancy or breastfeeding
  • Use of topical or systemic , drugs, or antihistamines
Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

Immunosuppression

A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.

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05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
40 participants (actual)
Patient registry
No

Groups and cohorts

  • Regular UV Nail Lamp Users

    Healthy adult women who regularly undergo nail treatments involving exposure to UV lamps.

  • Non-Users of UV Nail Lamps

    Healthy adult women who do not regularly undergo nail treatments involving exposure to UV lamps and have natural nails.

06

What researchers measure

Primary outcomes

  1. Change in Transepidermal Water Loss (TEWL)

    Skin barrier function will be assessed by measuring transepidermal water loss using a Tewameter TM 300 probe. Values will be expressed in g/m²/h

    Time frame: Day 1 (single study visit)

  2. Change in Skin Hydration

    Hydration of the stratum corneum will be assessed using a Corneometer CM 825 probe.

    Time frame: Day 1 (single study visit)

  3. Change in Skin Erythema

    Skin erythema will be assessed using a Mexameter MX 18 probe.

    Time frame: Day 1 (single study visit)

07

Study locations

1 site
  • University of Split School of Medicine
    Split, 2100, Croatia
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Status
Recruiting→Completed
changed Oct 6, 2026
Start date
Jul 2026→Jan 12, 2026 (actual)
Oct 6, 2026
Primary completion
Jul 2027→Jun 29, 2026 (actual)
Oct 6, 2026
Study completion
Jul 2027→Jun 29, 2026 (actual)
Oct 6, 2026
Enrollment
30 (estimated)→40 (actual)
Oct 6, 2026
Show all 1 update
  1. Oct 6, 2026
    Recruiting→Completed
    Start date Jul 2026→Jan 12, 2026 (now actual)
    Primary completion Jul 2027→Jun 29, 2026 (now actual)
    Study completion Jul 2027→Jun 29, 2026 (now actual)
    Enrollment 30 (estimated)→40 (actual)
    + 3 other changes: verification date, contact details and site details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07700186
Lead sponsor
University of Split, School of Medicine
Responsible party
Sponsor
First posted
Jul 13, 2026
Start date
Jan 12, 2026
Primary completion
Jun 29, 2026
Completion
Jun 29, 2026
Last update
Oct 6, 2026

Study contacts

Josipa Bukić
principal investigator · University of Split, School of Medicine

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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