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CompletedNCT07697963Updated Jul 13, 2026

Evaluation of Photodynamic Therapy as an Adjunct to Non-surgical Treatment in Periodontitis in Smokers vs. Non-smokers

An Early Phase 1 interventional study of Scaling and root planing plus placebo and Photodynamic therapy (PDT) in Periodontal Disease, sponsored by University of Pristina. Completed. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-13.

Sponsored by University of Pristina · Early Phase 1, Interventional, and Treatment

From the registry’s dates

  • Registered 11 years 6 months after the study started (first participant enrolled Jan 2015, registered Jul 2026).
Phase
Early Phase 1
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
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Study summary

Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. This comparison between two treatment options was evaluated between subjects who smoke and non-smokers.

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Conditions studied

  • Periodontal Disease

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Keywords

  • photodynamic therapy
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In context

Periodontal Diseases

830 studies on the registry are indexed under Periodontal Diseases; 188 are open to participants now.

This study's enrollment of 120 is above the median of 45 across 530 interventional studies indexed under Periodontal Diseases.

Browse Periodontal Diseases studies →

Lead sponsor

University of Pristina is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • at least two teeth with periodontal pockets up to 4 mm

Exclusion criteria

Exclusion Criteria:

  • less than two teeth with periodontal pockets
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Study design

Phase
Early Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
120 participants (actual)

Study arms

  • Active comparator
    Scaling and root planning

    Non-surgical treatment

    Procedure: Scaling and root planing plus placebo

  • Experimental
    Photodynamic therapy

    Application of photodynamic therapy as an adjunct to non-surgical therapy

    Combination Product: Photodynamic therapy (PDT)

Interventions

  • ProcedureScaling and root planing plus placebo

    Non-surgical treatment of periodontal pockets

    Also known as: scaling and root planning

  • Combination productPhotodynamic therapy (PDT)

    Photodynamic therapy was applied to a previously treated pocket with non-surgical therapy

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What researchers measure

Primary outcomes

  1. Periodontal pocket depth reduction

    Time frame: 6 weeks

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07697963
Lead sponsor
University of Pristina
Responsible party
Kastriot Meqa (Dr, University of Pristina) — Principal investigator
First posted
Jul 13, 2026
Start date
Jan 5, 2015
Primary completion
Oct 15, 2015
Completion
Dec 15, 2015
Last update
Jul 13, 2026
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.

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