An observational study in Periodontitis, sponsored by Giresun University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 27 Years to 49 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-10.
Sponsored by Giresun University · Observational
This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.
Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 60 is below the median of 90 across 428 observational studies indexed under Periodontitis.
Browse Periodontitis studies →Giresun University is the lead sponsor of 51 studies on the registry; 4 are open to participants now.
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Criteria for healthy control group: BOP \< 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction.
Criteria for periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.
Exclusion Criteria:
Procedure: Nonsurgical periodontal therapy
Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.
1. Adropin levels
Changes in Adropin levels before and after periodontal therapy
Time frame: Baseline and at 6 weeks after therapy
TNF-alfa levels
Changes in TNF-alfa levels before and after periodontal therapy
Time frame: baseline and at 6 weeks after therapy
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Giresun University