An observational study in Critical Illness, Delirium in the Intensive Care Unit and Sleep Quality, sponsored by Scripps Health. Recruiting at 2 sites in United States. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-07-09.
Sponsored by Scripps Health · Observational
The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive care unit (ICU). The main question DELTA aims to answer is:
Can digital biometrics predict and detect delirium in older adult ICU patients? Do biomarkers of neurodegeneration fluctuate in ICU patients in such a way that delrium could potentially be predicted?
Participants admitted o the ICU will wear a digital device to collect biometric data and will have serial plasma samples collected during ICU admission and patients will be also assessed for delirium daily by study staff.
1,881 studies on the registry are indexed under Critical Illness; 462 are open to participants now.
This study's planned enrollment of 100 is below the median of 130 across 867 observational studies indexed under Critical Illness.
Browse Critical Illness studies →Scripps Health is the lead sponsor of 45 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Critically ill older adults.
Exclusion Criteria:
This is the main cohort in which all participants will be enrolled in. These individuals are older adults admitted to the intensive care unit (ICU) with an expected stay of at least 48 hours. Broadly, individuals cannot have advanced dementia at baseline, have liver cirrhosis or be on any kind of renal replacement therapy.
Delirium
Delirium incidence as assessed by the CAM-ICU instrument.
Time frame: Between enrollment and ICU discharge, up to a maximum of 10 days.
Sleep Duration
Daily total sleep duration as measured by actigraphy
Time frame: Between enrollment and ICU discharge up to a maximum 10 days in the ICU.
Sleep fragmentation
Nightly sleep fragmentation as measured by actigraphy
Time frame: Nightly between enrollment and ICU discharge, up to a maximum of 10 days.
Circadian activity rhythm disruption
Using daily activity/temperature/heart rate, circadian activity rhythms will be assessed for goodness of fit to a cosinor curve.
Time frame: Daily between enrollment and ICU discharge, up to a maximum of 10 days.
Delirium duration
As measured by CAM-ICU
Time frame: between enrollment and ICU discharge up to a maximum of 10 days
Plan to share: Yes — Deidentified participant data will be shared upon reasonable request from the principal investigator. A data dictionary will be provided.
Supporting information: Study protocol, Icf
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Scripps Health