A Phase 2/3 interventional study of Sustained thrombectomy and Percutaneous Coronary Intervention in STEMI - ST Elevation Myocardial Infarction, sponsored by Oxford University Hospitals NHS Trust. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-10.
Sponsored by Oxford University Hospitals NHS Trust · Phase 2/3, Interventional, and Treatment
The CAPTURE AMI trial is an investigator-initiated, single-centre, two-arm, randomised controlled trial. Patients aged ≥ 18 years who present with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) will be enrolled after angiographic evidence of a high thrombus burden (TIMI thrombus grade ≥ 4) and meeting the inclusion criteria laid out in section 9.2 will be 1:1 randomised to receive either standalone PCI (Arm 1) or adjunct sustained mechanical thrombectomy + PCI (Arm 2).
The CAPTURE AMI study will enrol specifically patients with:
A. Evidence of high thrombus burden on coronary angiography (TIMI thrombus grade ≥ 4) B. Culprit in an artery with a diameter of 3.0 mm or more. The trial is designed to evaluate the efficacy of sustained mechanical thrombectomy versus standalone PCI in patients with a large thrombus burden assessed angiographically, with a pre-stent thrombus burden (%) as the primary imaging endpoint.
850 studies on the registry are indexed under ST Elevation Myocardial Infarction; 197 are open to participants now.
This study's planned enrollment of 60 is below the median of 194 across 527 interventional studies indexed under ST Elevation Myocardial Infarction.
Browse ST Elevation Myocardial Infarction studies →Oxford University Hospitals NHS Trust is the lead sponsor of 94 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Angiographic criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).
Hemoglobin (Hb)
The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Standalone OCT guided PCI
Procedure: Percutaneous Coronary Intervention
OCT guided PCI \& Sustained Thrombectomy
Device: Sustained thrombectomy · Procedure: Percutaneous Coronary Intervention
Sustained thrombectomy with the Indigo® System CAT™ RX aspiration catheter
Optical Coherence Tomography guided Percutaneous Coronary Intervention
Pre stent Thrombus Burden
Pre stent Thrombus Burden (thrombus volume/lumen volume) evaluated by Optical Coherence Tomography
Time frame: Pre stent implantation (Periprocedural)
Clinical Outcomes
Rate of major adverse cardiac and cerebrovascular events (MACCE)
Time frame: In hospital (Pre-discharge), 30 days & 6 months
Efficacy of thrombus burden reduction
Thrombus volume (mm3) by Optical Coherence Tomography
Time frame: Pre stent implantation (Periprocedural)
Efficacy of thrombus burden reduction
Thrombus area, flow area (mm2) by Optical Coherence Tomography
Time frame: Pre stent Implantation (Periprocedural)
Efficacy of thromboatheroma reduction
Thromboatheroma volume (mm3), flow volume (mm3) by Optical Coherence Tomography
Time frame: Post stent implantation (Periprocedural)
Efficacy of target vessel reperfusion
Coronary Flow Reserve (CFR) and Index of Microcirculatory Resistance (IMR) assessment in target vessel
Time frame: Post stent Implantation (Periprocedural)
Efficacy of stent implantation
Stent expansion \& apposition by Optical Coherence Tomography
Time frame: Post stent implantation (Periprocedural)
Plan to share: Undecided
Started Jul 2026 (actual). Primary completion is estimated for Jul 2027, 12 months after the start.
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ST Elevation Myocardial Infarction →
Oxford University Hospitals NHS Trust