An observational study in Breast Cancer (Triple Negative Breast Cancer (TNBC)), sponsored by Assistance Publique - Hôpitaux de Paris. Not yet recruiting. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-07.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
The goal of this observational, retrospective, non interventional study is to learn about the efficacy of an Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Early Triple-Negative Breast Cancer (TNBC).
The main question it aims to answer is :
- What is the efficacy of this kind of treatment, by evaluating the pathological complete response (PCR), that is to say, the percentage of patients where no tumor cells remained when they underwent surgery after neoadjuvant treatment.
The other points that will be evaluated are:
The standard treatment for localized TNBC (larger than 2 cm or with lymph node involvement) is neoadjuvant chemoimmunotherapy, which includes anthracyclines. However, in real-world practice, some patients have a contrindication to this treatment because they have received it previously, are too old, or have comorbidities, particularly cardiovascular disease. Currently, there is limited data on the modalities and efficacy of such treatment.
12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.
This study's planned enrollment of 100 is below the median of 184 across 2,642 observational studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with early Triple-Negative Breast Cancer treated with an anthracycline-Free Neoadjuvant Chemoimmunotherapy
Exclusion Criteria:
Other: Non interventional study
Non interventional Study
Pathological Complete Response (PCR)
Time frame: At Surgery
Adverse Effects
Time frame: 6-48 months according to treatment start
Epidemiologic description of the population treated
Time frame: Baseline
Type of treatment anthracycline-free
Time frame: Baseline
No study locations are listed for this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris