A Phase 4 interventional study of dexamethasone and Cold Saline in Symptomatic Irreversible Pulpitis (SIP), sponsored by October 6 University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-30.
Sponsored by October 6 University · Phase 4, Interventional, and Prevention
The aim of the study: is to evaluate efficiency of using either intracanal corticosteroids or intracanal cryotherapy as a final flush irrigation on post endodontic pain in lower molar teeth with symptomatic irreversible pulpitis. The materials and methods: In this study forty patients with symptomatic irreversible pulpitis in lower molar teeth with pain level of 4 or higher on the visual analogue scale (VAS) will be selected.
This study will involve 40 adult patients (18-60 years) for both genders equally .all of patients must provide written informed consent and commit to the full trial period. Eligible participants must present with a lower molar diagnosed with symptomatic irreversible pulpitis, characterized by moderate-to-severe preoperative pain (VAS score ≥ 4) that lingers after stimulus removal. Conversely, the study excludes vulnerable groups (e.g., pregnant or mentally ill), medically compromised individuals, and those who have taken analgesics or antibiotics. Specific dental exclusions include teeth with open apices, calcified canals, prior endodontic treatment, or periodontally affected tooth
2,219 studies on the registry are indexed under Pain; 915 are open to participants now.
This study's enrollment of 40 is below the median of 70 across 1,901 interventional studies indexed under Pain.
Browse Pain studies →October 6 University is the lead sponsor of 135 studies on the registry; 27 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
After completing a cleaning and shaping and before obturation the canal rinsed with saline 20 ml for 5 min at room temperature with side vented needle
After completing a cleaning and shaping and before obturation the canal rinsed with sodium hypochlorite 20 ml for 5 min at room temperature with side vented needle
intra root canal final flush of 5ml of 4mg/ml dexamethasone before obturation
Drug: dexamethasone
intra root canal final flush of 20ml of cold saline before obturation
Other: Cold Saline
intra root canal final flush of 20ml of cold sodium hypochlorite before obturation
Other: cold sodium hypochlorite
intra root canal final flush of 5ml of 4mg/ml dexamethasone before obturation
intra root canal final flush of 20ml of cold saline before obturation
intra root canal final flush of 20ml of cold sodium hypochlorite before obturation
postoperative pain
assessment of post operative pain after single visit root canal treatment using vasual analogue scale
Time frame: 1 year
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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October 6 University