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CompletedNCT07662434Updated Oct 1, 2026

A Prospective , Split-mouth, Clinical Study of Orthodontic Titanium Miniscrews With Machined and Acid-etched Surfaces.

An interventional study of miniscrews placement in Malaligned Teeth and Crowding, sponsored by Foundation University Islamabad. Completed at 1 site in Pakistan. Open to participants aged 13 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-01.

Sponsored by Foundation University Islamabad · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 11 months after the study started (first participant enrolled Jun 2024, registered Jun 2026).
Updated Oct 1, 2026Enrollment updatedGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
13 Years to 25 Years
Sex
All
01

Study summary

Primary goal of this study to check the stability of miniscrews used in orthodontic treatment in order to evaluate the success of the treatment.

Read the detailed description

Aim of the study is to compare the success rate and primary stability of surface treated versus non-treated miniscrews. Stability of screws is the major concern for an orthodontist during treatment. Surface treatment actually modify the surface by making it rough resulting in increase in surface area which provide better stability.

02

Conditions studied

  • Malaligned Teeth
  • Crowding

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Keywords

  • Miniscrews
  • Acid-etched Miniscrews
03

In context

Crowding

88 studies on the registry are indexed under Crowding; 22 are open to participants now.

This study's enrollment of 40 is above the median of 36 across 74 interventional studies indexed under Crowding.

Browse Crowding studies →

Lead sponsor

Foundation University Islamabad is the lead sponsor of 255 studies on the registry; 142 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
13 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Fixed appliance treatment with or without premolar extraction One or more miniscrews for same reason in each quadrant of maxilla or mandible Patient over 13 years Patient with permanent dentition\ Treatment plan should include miniscrews

Exclusion criteria

Exclusion Criteria:

  • Severe craniofacial deformities such as cleft lip and palate History of bone disease Cases with high expectation of failure due to anatomical limitation such as sinus pneumatization Narrow interproximal alveolar bone Attached gingiva deficiency Mixed Dentition
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Single group
Masking
Single (Participant)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    experimental group: Acid etcehd miniscrews

    Placement of surface treated screws

    Device: miniscrews placement

  • Placebo comparator
    Control Group with conventional miniscrews

    Non-surface treated miniscrews

    Device: miniscrews placement

Interventions

  • Deviceminiscrews placement

    Placement of miniscrews under local anesthesia in both groups

06

What researchers measure

Primary outcomes

  1. Primary Stability of of machined and acid-etched miniscrews

    Absence of clinical stability of miniscrews (\>1mm)

    Time frame: After one month of insertion

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Study locations

1 site
  • Foundation University College of Dentistry and Hospital
    Islamabad, Federal 44000, Pakistan
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References and documents

Publications

  • Yoo SH, Park YC, Hwang CJ, Kim JY, Choi EH, Cha JY. A comparison of tapered and cylindrical miniscrew stability. Eur J Orthod. 2014 Oct;36(5):557-62. doi: 10.1093/ejo/cjt092. Epub 2013 Dec 19. PubMed 24355870 ↗
  • Chen YJ, Chang HH, Huang CY, Hung HC, Lai EH, Yao CC. A retrospective analysis of the failure rate of three different orthodontic skeletal anchorage systems. Clin Oral Implants Res. 2007 Dec;18(6):768-75. doi: 10.1111/j.1600-0501.2007.01405.x. Epub 2007 Sep 14. PubMed 17868386 ↗
  • Chang C, Liu SS, Roberts WE. Primary failure rate for 1680 extra-alveolar mandibular buccal shelf mini-screws placed in movable mucosa or attached gingiva. Angle Orthod. 2015 Nov;85(6):905-10. doi: 10.2319/092714.695.1. Epub 2015 Jan 20. PubMed 25603272 ↗
  • Choi SH, Jang SH, Cha JY, Hwang CJ. Evaluation of the surface characteristics of anodic oxidized miniscrews and their impact on biomechanical stability: An experimental study in beagle dogs. Am J Orthod Dentofacial Orthop. 2016 Jan;149(1):31-8. doi: 10.1016/j.ajodo.2015.06.020. PubMed 26718375 ↗
  • Gansukh O, Jeong JW, Kim JW, Lee JH, Kim TW. Mechanical and Histological Effects of Resorbable Blasting Media Surface Treatment on the Initial Stability of Orthodontic Mini-Implants. Biomed Res Int. 2016;2016:7520959. doi: 10.1155/2016/7520959. Epub 2016 Jan 28. PubMed 26942200 ↗
  • Park HJ, Choi SH, Choi YJ, Park YB, Kim KM, Yu HS. A prospective, split-mouth, clinical study of orthodontic titanium miniscrews with machined and acid-etched surfaces. Angle Orthod. 2019 May;89(3):411-417. doi: 10.2319/031618-211.1. Epub 2018 Dec 5. PubMed 30516419 ↗

Individual participant data

Plan to share: No — Patient privacy

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jun 2024 to primary completion in Oct 2025, 15 months.

Of 50 non-industry interventional studies with no phase under Crowding, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 28. This study's 15 months is below that.

Counting every sponsor, half of 52 studies reached it within 17 months; a quarter within 11 and three quarters within 28.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 11, 2026
First posted
Jun 23, 2026
StartActual
Jun 20, 2024
Primary completionActual
Oct 2, 2025
CompletionActual
Dec 2, 2025
Last update
Oct 1, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Enrollment
30→40
Oct 1, 2026
Show all 1 update
  1. Oct 1, 2026
    Enrollment 30→40

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07662434
Responsible party
Shoaib Rahim (Associate Professor, Foundation University Islamabad) — Principal investigator
First posted
Jun 23, 2026
Start date
Jun 20, 2024
Primary completion
Oct 2, 2025
Completion
Dec 2, 2025
Last update
Oct 1, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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