An interventional study of supplementation, food in Prediabetes, Obesity & Overweight and Inflamation, sponsored by National and Kapodistrian University of Athens. Not yet recruiting at 1 site in Greece. Open to participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-22.
Sponsored by National and Kapodistrian University of Athens · Not applicable, Interventional, and Prevention
Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects. These so-called food bioactives (FB) are converted in the human organism, in particular by the gut microbiota and microsomal (liver/intestinal) metabolism, into numerous metabolites, which often represent the actual biologically active molecules. As part of the European HORIZON-MSCA Doctoral Network "BioTransform," two such food models are being studied as examples: 1. Olive products (Olea europaea L.) - representative of the Mediterranean diet, rich in secoiridoids and phenylethanols (especially hydroxytyrosol and tyrosol). 2.
Bilberry /blueberry (Vaccinium myrtillus L.) - representative of the Central European diet, rich in anthocyanosides. Two parallel human intervention studies will be conducted, one in Graz (WP1, DC5) and one in Athens (WP1, DC3). These pilot studies will generate biological samples (blood, urine, stool) and investigate the extent to which taking these standardized dietary supplements influences glucose metabolism and markers of oxidative stress and low-grade inflammation.
Exclusion Criteria:
Group of 20 people will receive olive oil extract supplements and after the washout period will receive placebo.
Dietary Supplement: supplementation, food
Group of 20 participants will receive bilberry extract supplements and after the washout period a placebo phase.
Dietary Supplement: supplementation, food
Through this pilot clinical study, the possible change of inflammatory and oxidative stress biomarkers in prediabetic, overweigh/ obese people will be observed. Blood, urine and stool samples will be collected, while weight mangment will also be controlled.
Also known as: Body weight and composition changes, oxidative stress and inflammatory biomarkers, blood samples, urine samples, stool samples
Changes in inflammatory and oxidative stress markers
The changes in the inflammatory and oxidative stress markers will be assessed through blood samples and the biomarkers: hsCRP, IL-6, TNF-a, total antioxidant capacity, ratio glutathione/ oxidiced glutathion
Time frame: 14 weeks
Lipid profile
Blood samples: TCHOL, HDL, LDL, TG
Time frame: 14 weeks
Inflammatory profile
Blood samples: ICAM-1, VCAM-1, CRP-C
Time frame: 14 weeks
Anthropometric profile
Body measurements: BMI and body weight changes
Time frame: 14 weeks
Metabolic profile
Urine and plasma samples: metabolite profile in urine and plasma
Time frame: 14 weeks
Microbiome profile
Stool samples: microbiome diversity, microbiome composition changes, and microbiome functionality
Time frame: 14 weeks
This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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National and Kapodistrian University of Athens