ClinicalTrials.gg
Not yet recruitingNCT07654101Updated Jun 17, 2026

Isometric Hand-Grip Exercise for Preventing Thrombosis and Occlusion of Midline Venous Catheters: A Randomized Controlled Trial

An interventional study of handgrip in Midline Catheter, sponsored by University Hospital Padova. Not yet recruiting. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-06-17.

Sponsored by University Hospital Padova · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
840
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

evaluate whether hand-grip ball exercises reduce thrombosis and occlusions of Midline catheters in hospitalized patients.

Read the detailed description

The proposed intervention consists of low-intensity, short-duration, non-invasive, and non-pharmacological exercises, with an expected minimal risk profile. The aim of the study is therefore to systematically evaluate the effectiveness and safety of this practice in patients with Midline catheters, in a context of genuine scientific uncertainty, in order to generate evidence useful for clinical practice.

Primary objective To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.

Associated endpoints

Incidence of Midline thrombosis (%) confirmed by ultrasound.

02

Conditions studied

  • Midline Catheter

Keywords

  • midline
  • occlusion
  • handgrip
03

In context

Lead sponsor

University Hospital Padova is the lead sponsor of 41 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Midline catheter insertion for planned intravenous therapy lasting ≥ 7 days. Age between 18 and 70 years. Catheter inserted in the upper limb (forearm). Ability to understand and perform hand exercises with the limb bearing the venous catheter.

Written .

Exclusion criteria

Exclusion Criteria:

  • Pre-existing superficial or deep venous thrombosis of the limb used for the Midline catheter.

Limb injuries or amputations. Motor or neurological impairment of the hand. \< 7 days. Cognitive impairment/delirium. Medical to active upper-limb movement.

Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Life expectancy

The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
840 participants (estimated)

Study arms

  • No intervention
    standard

    usual care

  • Experimental
    handgrip

    use of handgrip exercises in patients with midline catether

    Other: handgrip

Interventions

  • Otherhandgrip

    handgrip in patients with midline catethers

06

What researchers measure

Primary outcomes

  1. To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.

    Incidence of Midline thrombosis (%) confirmed by ultrasound.

    Time frame: from enrollment until catether removal

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Jul 2026; primary completion for May 2027, 9 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 11, 2026
First posted
Jun 17, 2026
StartEst.
Jul 6, 2026
Primary completionEst.
May 1, 2027
CompletionEst.
Sep 1, 2027
Last update
Jun 17, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 17, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07654101
Lead sponsor
University Hospital Padova
Responsible party
Cesaro Elisabetta (PI Degan Mario, University Hospital Padova) — Principal investigator
First posted
Jun 17, 2026
Start date
Jul 6, 2026 (estimated)
Primary completion
May 1, 2027 (estimated)
Completion
Sep 1, 2027 (estimated)
Last update
Jun 17, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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