An observational study in Percutaneous Nephrolithotomy (PNL) and Nephrolithiasis, sponsored by Ankara Education and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-06-17.
Sponsored by Ankara Education and Research Hospital · Observational
Among 26 studies in Nephrolithiasis with a site in Turkey — 6 open to participants now, 7 under way, none of them phase 3. Nephrolithiasis · Turkey.
Among the 26 studies in Nephrolithiasis with a site in Turkey, this one is the 10th largest by enrollment of the 11 observational ones, is one of 5 that started in 2024, is one of 11 observational ones, and was the 21st registered.
324 studies on the registry are indexed under Nephrolithiasis; 90 are open to participants now.
This study's enrollment of 60 is below the median of 100 across 57 observational studies indexed under Nephrolithiasis.
Browse Nephrolithiasis studies →6 of the 26 studies in Nephrolithiasis with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 51 Nephrolithiasis studies recruiting now, 30 (59%) set no upper age limit and 14 (27%) stop at 75 or younger; 2 take children under 18; 7 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · no healthy volunteers.
The full table on the hub →26 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 5 started in 2024.
Median enrollment 84 across the 15 interventional studies, 105 across the 11 observational. Of the 16 that completed or were terminated, 0 (0%) have results posted.
None of the 26 has an industry lead sponsor. The 10 most frequent:
Ankara Education and Research Hospital is the lead sponsor of 14 studies on the registry; none are open to participants now.
Ankara Education and Research Hospital has 1 study filed under Nephrolithiasis — fewer than ten, so there is no comparison to draw.
3 of the studies in Nephrolithiasis with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07705646Sultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyComparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery | 2026-11-15 |
| NCT07866209Antalya Health Sciences UniversityComparison of Suction and Conventional Ureteral Access Sheaths in Kidney Stone Surgery | 2027-03-30 |
| NCT07898020Ondokuz Mayıs UniversityUreteral Access Strategies in Retrograde Intrarenal Surgery | 2027-07-01 |
Among the 26 studies in Nephrolithiasis with a site in Turkey, from their registry updates:
People who undergo percutaneous nephrolithotomy (PNL), a procedure used to remove kidney stones, often experience pain after surgery. An ultrasound-guided erector spinae plane block (ESPB) is commonly used to help reduce this pain.
This study compares two different concentrations of bupivacaine, a local anesthetic medication, used during ESPB. Participants undergoing PNL will receive either 0.25% or 0.375% bupivacaine as part of their pain management.
Researchers will compare pain scores, the need for additional pain medication, and changes in blood markers related to inflammation after surgery. The aim of the study is to determine whether one concentration provides better pain control or influences the inflammatory response differently after PNL.
Percutaneous nephrolithotomy (PNL) is the standard treatment for large and complex renal stones. Despite its minimally invasive nature, postoperative pain remains an important clinical concern and may adversely affect recovery, mobilization, and patient satisfaction. Ultrasound-guided thoracic erector spinae plane block (ESPB) has been increasingly incorporated into multimodal analgesia protocols because of its simplicity, safety profile, and effectiveness in reducing postoperative pain.
The optimal concentration of bupivacaine for ESPB in patients undergoing PNL remains unclear. This study was designed to compare the effects of two different concentrations of bupivacaine (0.25% and 0.375%) administered during ultrasound-guided thoracic ESPB on postoperative pain control and inflammatory response following PNL.
Adult patients scheduled for elective PNL were enrolled. ESPB was performed at the T10 vertebral level under ultrasound guidance before surgery. Participants received 20 mL of either 0.25% or 0.375% bupivacaine. Standard perioperative anesthetic and postoperative analgesic protocols were applied to all participants.
The primary outcome was postoperative pain intensity assessed using Visual Analog Scale (VAS) scores at predefined postoperative time points. Secondary outcomes included intraoperative fentanyl consumption, postoperative tramadol consumption, patient-controlled analgesia requirements, postoperative nausea and vomiting, patient satisfaction, and perioperative changes in inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
Demographic characteristics, stone-related variables, operative data, and perioperative hemodynamic parameters were recorded. Statistical analyses were performed to compare postoperative pain outcomes, analgesic requirements, and inflammatory biomarker responses between the study groups.
The study population consisted of adult patients undergoing elective percutaneous nephrolithotomy (PNL) for renal stone disease at a single tertiary care center between July 2024 and March 2025. Eligible participants were 18-70 years of age, classified as American Society of Anesthesiologists (ASA) physical status I-III, and received ultrasound-guided thoracic erector spinae plane block (ESPB) as part of perioperative analgesic management. A total of 60 participants were included and prospectively followed throughout the postoperative period.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
0.25% Bupivacaine ESPB
Procedure: Erector spinae plane block (ESPB)
0.375% bupivacaine ESPB
Procedure: Erector spinae plane block (ESPB)
Ultrasound-guided thoracic erector spinae plane block was performed at the T10 vertebral level before surgery by an experienced anesthesiologist. A total volume of 20 mL bupivacaine was administered. Participants received either 0.25% or 0.375% bupivacaine according to the study cohort. The block was used as part of a multimodal analgesia protocol for postoperative pain management following percutaneous nephrolithotomy.
Postoperative pain intensity assessed using the Visual Analog Scale (VAS) and total opioid consumption
Postoperative pain intensity was assessed using the Visual Analog Scale (VAS; 0-10), where higher scores indicate greater pain severity. Pain scores and Total intraoperative and postoperative opioid consumption were recorded at 1, 3, 6, 12, 24, and 36 hours after surgery.
Time frame: 36 hours after surgery
inflammatory markers
Changes in neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio measured before surgery and at 12 and 24 hours after surgery.
Time frame: 24 hours after surgery
Plan to share: No — Individual participant data will not be made publicly available because the informed consent obtained from participants did not include permission for public data sharing, and data confidentiality and privacy will be maintained in accordance with institutional and ethical requirements.
Ran from Jul 2024 to primary completion in Mar 2025, 8 months.
Of 27 observational studies under Nephrolithiasis, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 54. This study's 8 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Ankara Education and Research Hospital