An observational study in Prediabetes, Hyperglycemia and Metabolic Syndrome, sponsored by Medical Center TOPMED. Recruiting at 1 site in Romania. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-17.
Sponsored by Medical Center TOPMED · Observational
This prospective observational study investigates the association between personality traits and routine laboratory abnormalities in adults undergoing routine health assessment. Personality traits are assessed using the Five-Factor Personality Inventory (FFPI), while biochemical data are obtained from routine laboratory testing, including markers of glycemic status, liver function, lipid metabolism, renal function, and complete blood count parameters.
The primary objective of the study is to evaluate the association between FFPI personality trait scores and the total number of laboratory abnormalities identified during routine clinical evaluation. Secondary analyses will examine associations between personality traits and glycemic status, fasting plasma glucose concentration, liver function markers, lipid profile parameters, renal function indicators, complete blood count parameters, and the total number of laboratory abnormalities.
The findings may contribute to a better understanding of the relationship between psychological characteristics and biological health indicators and may support the development of more personalized approaches to health promotion, risk assessment, and disease prevention.
The study is designed as a prospective observational cohort investigation conducted in adults undergoing routine health assessment. Participants complete the Five-Factor Personality Inventory (FFPI), and clinical and laboratory data are collected as part of routine medical evaluation.
Routine laboratory assessment includes fasting plasma glucose (mg/dL), gamma-glutamyl transferase (GGT, U/L), alanine aminotransferase (ALT, U/L), aspartate aminotransferase (AST, U/L), total cholesterol (mg/dL), serum creatinine (mg/dL), urea (mg/dL), estimated glomerular filtration rate (eGFR, mL/min/1.73 m²), and complete blood count parameters measured according to standard laboratory units. The total number of laboratory abnormalities is defined as the count of laboratory parameters outside their corresponding reference intervals. For the purposes of this study, the total number of laboratory abnormalities serves as an operational indicator of biochemical risk.
The primary objective of the study is to evaluate the association between Five-Factor Personality Inventory (FFPI) personality trait scores and the total number of routine laboratory abnormalities identified during clinical evaluation.
Secondary analyses will examine associations between personality traits and glycemic status, fasting plasma glucose concentration, liver function markers (GGT, ALT, and AST), lipid profile parameters, renal function indicators, and the total number of laboratory abnormalities.
Data are collected prospectively during routine clinical practice. Statistical analyses will evaluate the strength and direction of associations between personality traits and laboratory health indicators while accounting for relevant demographic and clinical variables.
918 studies on the registry are indexed under Prediabetic State; 232 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 224 across 129 observational studies indexed under Prediabetic State.
Browse Prediabetic State studies →Medical Center TOPMED is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Adults undergoing routine health assessment in a clinical setting who complete the Five-Factor Personality Inventory (FFPI) and have routine laboratory data available for evaluation of laboratory health indicators and their association with personality traits.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
This cohort includes adults undergoing routine health assessment who complete the Five-Factor Personality Inventory (FFPI) and have biochemical laboratory data available from routine clinical evaluation. Collected variables include indicators of glycemic status, liver function, lipid metabolism, renal function, and complete blood count parameters obtained during routine laboratory assessment. Participants undergo routine laboratory assessment, and the total number of laboratory abnormalities is determined based on the count of laboratory parameters outside the corresponding reference intervals. These data are used to evaluate associations between personality traits and biological health indicators.
Number of Laboratory Abnormalities
Total number of routine laboratory parameters outside their corresponding reference intervals, expressed as a count of abnormal laboratory findings. Laboratory parameters include fasting plasma glucose (mg/dL), gamma-glutamyl transferase (GGT, U/L), alanine aminotransferase (ALT, U/L), aspartate aminotransferase (AST, U/L), total cholesterol (mg/dL), serum creatinine (mg/dL), urea (mg/dL), estimated glomerular filtration rate (eGFR, mL/min/1.73 m²), and complete blood count parameters measured according to standard laboratory units.
Time frame: At baseline
Five-Factor Personality Inventory (FFPI) Scores
Personality traits assessed using the Five-Factor Personality Inventory (FFPI), including Neuroticism, Extraversion, Agreeableness, Conscientiousness, and Openness dimensions, expressed as standardized questionnaire scores.
Time frame: At baseline
Glycemic Status
Classification of participants according to fasting plasma glucose (mg/dL) concentration measured during routine laboratory assessment as: Normoglycemia (\<100 mg/dL) Prediabetes (100-125 mg/dL) Hyperglycemia (≥126 mg/dL or previously diagnosed diabetes mellitus)
Time frame: At baseline
Plan to share: Undecided — Any future data sharing will be considered in accordance with institutional policies, ethical approvals, participant confidentiality requirements, and applicable data protection regulations.
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