An interventional study of Enhanced Recovery After Surgery and Conventional Postoperative Care in Emergency Laparotomy, Intestinal Obstruction and Intestinal Perforation, sponsored by Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh. Completed at 1 site in Pakistan. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-16.
Sponsored by Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh · Not applicable, Interventional, and Prevention
This study aims to compare an Enhanced Recovery After Surgery (ERAS) protocol with conventional postoperative care in adults undergoing emergency laparotomy for intestinal obstruction or intestinal perforation.
The main question this study aims to answer is:
Researchers will also compare other recovery outcomes between the two groups, including length of hospital stay, occurrence of paralytic ileus (temporary loss of bowel function), time to first bowel movement, and time to start taking fluids by mouth after surgery.
A total of 102 participants will be enrolled and randomly assigned to one of two groups. One group will receive postoperative care according to the ERAS protocol, while the other group will receive conventional postoperative care. All participants will undergo emergency laparotomy using standard surgical and anesthetic techniques.
Participants will:
The researchers hypothesize that patients managed with the ERAS protocol will have a lower frequency of surgical site infections and improved postoperative recovery compared with those receiving conventional care.
104 studies on the registry are indexed under Intestinal Obstruction; 15 are open to participants now.
This study's enrollment of 102 is above the median of 62 across 54 interventional studies indexed under Intestinal Obstruction.
Browse Intestinal Obstruction studies →Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants undergoing emergency laparotomy will receive postoperative care according to the Enhanced Recovery After Surgery (ERAS) protocol.
Procedure: Enhanced Recovery After Surgery
Participants undergoing emergency laparotomy will receive standard postoperative care as routinely practiced in the surgical unit.
Procedure: Conventional Postoperative Care
A standardized multimodal perioperative care pathway applied to patients undergoing emergency laparotomy. The protocol includes pre-defined components for preoperative optimization, intraoperative management, and postoperative care. Postoperative elements include early mobilization, early initiation of oral fluids and diet, optimized multimodal analgesia, early removal of tubes/drains when appropriate, and structured fluid management.
Standard postoperative management routinely practiced in the surgical unit for patients undergoing emergency laparotomy. Care includes traditional postoperative monitoring, routine analgesia, delayed initiation of oral intake, standard mobilization practices, and conventional fluid and supportive management.
Surgical Site Infection
Frequency of surgical site infection (superficial and deep) occurring within 30 days after emergency laparotomy will be assessed and compared between the Enhanced Recovery After Surgery (ERAS) group and the conventional care group. Surgical site infection will be defined and classified according to standard surgical infection criteria as specified in the study protocol
Time frame: From enrollment within 30 days postoperatively
Hospital Stay
Length of hospital stay will be measured in days from the day of surgery until final disposition (discharge or death).
Time frame: From surgery to discharge within 30 days
Paralytic Ileus
Incidence of postoperative paralytic ileus defined as presence of abdominal distension with absence of bowel sounds on clinical examination (auscultation for at least one minute).
Time frame: From surgery till hospital stay within 30 days postoperatively
Time to First Stool
Time (in days) from surgery to passage of first postoperative stool, indicating return of bowel function.
Time frame: From surgery till hospital stay until discharge within 30 days postoperatively
Time to First Fluid Diet
Time (in days) from surgery to initiation and tolerance of first oral fluid intake postoperatively.
Time frame: Postoperatively during hospital stay till discharge within 30 days postoperatively
Plan to share: No
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This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh