An observational study in Small Bowel Adhesion, Obstruction Bowel and Adhesiolysis, sponsored by Astana Medical University. Enrolling by invitation at 1 site in Kazakhstan. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Astana Medical University · Observational
Abstract and Study Objectives Adhesive small bowel obstruction (ASBO) is a common indication for surgical intervention. Intra-abdominal adhesions are the leading cause of small bowel obstruction, particularly in patients with a history of previous abdominal surgery, which has been reported in up to 70-80% of cases.
Treatment strategies for small bowel obstruction depend on the clinical presentation and several patient- and disease-related factors, including the severity and duration of symptoms, the number of previous surgical procedures, comorbidities, and metabolic disorders. Clearer criteria are needed to determine which patients can be managed non-operatively, either in an outpatient or inpatient setting, and which require surgical intervention. Nevertheless, surgery may be necessary in up to 60% of cases.
Currently, there is no universally accepted surgical approach to adhesive small bowel obstruction, and the optimal role of open adhesiolysis versus laparoscopic adhesiolysis remains unclear. Our retrospective studies have shown encouraging results with laparoscopic adhesiolysis. However, prospective randomized studies remain limited, and the available evidence is insufficient to establish definitive treatment strategies, particularly in emergency and complex clinical situations. National-level analyses are also lacking, while some retrospective case series are subject to a substantial risk of selection bias and other methodological limitations.
Available clinical observations suggest that laparoscopic adhesiolysis may offer several advantages, including a shorter hospital stay and a potentially lower risk of readmission. Its minimally invasive nature may reduce postoperative pain and could potentially improve clinical outcomes. However, laparoscopic adhesiolysis carries a risk of inadvertent intraoperative bowel injury, including iatrogenic injury to the small intestine.
The primary aim of this study is to identify diagnostic and treatment strategies for patients presenting with adhesive small bowel obstruction in outpatient and inpatient settings by evaluating predictors of disease severity and treatment outcomes and subsequently developing an evidence-based surgical management algorithm.
The secondary objectives are:
104 studies on the registry are indexed under Intestinal Obstruction; 15 are open to participants now.
This study's planned enrollment of 1,500 is above the median of 107 across 40 observational studies indexed under Intestinal Obstruction.
Browse Intestinal Obstruction studies →Astana Medical University is the lead sponsor of 16 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study will be conducted at the national multicenter level, in regional (provincial) clinics among patients admitted on an emergency basis to surgical hospitals, including university clinics.
Inclusion Criteria: All patients with clinical, ultrasound, CT, or tomographic adhesive small bowel obstruction. If obstruction is not relieved by conservative methods (nasogastric tube, NGO) in accordance with international guidelines, including impaired passage of contrast (barium, Gastrografin), if it is not passed into the intestine within 8 hours (48-hour conservative treatment without Gastrografin® is permitted if Gastrografin® is (e.g., due to allergy) or is unavailable).
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Laparoscopic
Procedure: surgical operation
Laparoscopic
Procedure: surgical operation
Laparotomy
Procedure: surgical operation
Surgical intervention
Also known as: Laparoscopy
removal of adhesions, reduction of pain, recurrence of the disease and recovery
The frequency and location of adhesions in the abdominal cavity will be compared Pain, its intensity, and duration will be studied Patient physical activity after surgery Duration and frequency of intestinal paresis Frequency of compartment syndrome
Time frame: From enrollment to the end of treatment at 12 months
Plan to share: Undecided — The IPD cannot be provided temporarily, as patient registration is preliminary and data collection and analysis are ongoing. The final decision on shared use, as well as the source and amount of funding, will be made based on the analysis results.
No publications or documents are linked to this record.
Started Jan 2024 (actual). Primary completion is estimated for Jan 2029, 60 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Astana Medical University