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RecruitingNCT07643545Mito BurnUpdated Jun 11, 2026

Mitochondrial Energy Metabolism in Burns

An observational study in Burn Injury, sponsored by Arkansas Children's Hospital Research Institute. Recruiting at 1 site in United States. Open to participants aged 2 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-06-11.

Sponsored by Arkansas Children's Hospital Research Institute · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
125
Ages
2 Years to 80 Years
Sex
All
01

Study summary

The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study.

During the study, we will collect the following information:

  • General background information such as date of birth, height, weight, and other basic information.
  • Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests.
  • Blood, urine, and tissue during surgeries you have during your stay.
02

Conditions studied

  • Burn Injury

Browse trials for

03

Who can participate

Ages eligible
2 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Up to 125 patients (2 years to 80 years old) will be enrolled in this study. We will recruit both males and females requiring hospital admission to the ACH burn unit for burn care.

Inclusion criteria

  • Male or Female
  • Ages 2 years to 80 years
  • Requiring hospital admission for burn care
  • All races
  • All ethnicities

Exclusion criteria

Exclusion Criteria:

  • Age \< 2 years
  • Under 10 kg in body mass
  • Age > 80 years
  • Active pregnancy
  • Unable to provide informed consent and no legal authorized representative present
  • Patient is considered moribund at the time of admission by the treating physician.
04

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
125 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna
05

What researchers measure

Primary outcomes

  1. Blood Bioenergetics

    Peripheral Blood Mononuclear Cell (PBMC) respiration

    Time frame: Through study completion, an average of 1 year

Secondary outcomes

  1. Blood metabolics signatures

    Peripheral Blood Mononuclear Cell (PBMC) respiration

    Time frame: Through study completion, an average of 1 year

06

Study locations

1 of 1 sites recruiting
  • Arkansas Children's Hospital
    Little Rock, Arkansas 72202, United States
    • Craig Porter, PhD · Principal investigator
    • Esther Teo, MD · Sub investigator
    • Robert Maxson, MD · Sub investigator
    • Richard Yeager, MD · Sub investigator
    • Daniel Lozano, MD · Sub investigator
    • Mandy Yelvington, MS, OTR/L · Sub investigator
    Recruiting
07

Registry details

Key details

Study ID
NCT07643545
Lead sponsor
Arkansas Children's Hospital Research Institute
Collaborators
National Institute of General Medical Sciences (NIGMS)
Responsible party
Sponsor
First posted
Jun 11, 2026
Start date
Apr 20, 2023
Primary completion
Jun 2026 (estimated)
Completion
Jun 2026 (estimated)
Last update
Jun 11, 2026

Study contacts

Craig Porter, PhD
Contact
cporter@uams.edu
5013643340
Lily Cheak, B.S.
Contact
lcheak@uams.edu
5013643340
Craig Porter, PhD
principal investigator · Arkansas Children's Research Institute

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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