An interventional study of Esketamine and Normal Saline in Thyroidectomy and Coughing Reflex, sponsored by The Second Hospital of Anhui Medical University. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-04.
Sponsored by The Second Hospital of Anhui Medical University · Not applicable, Interventional, and Prevention
This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.
The Second Hospital of Anhui Medical University is the lead sponsor of 30 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
After anesthesia induction, continue to administer esketamine by infusion at 0.1 mg/kg/h during the maintenance phase of anesthesia, and stop the infusion of esketamine during suturing.
Drug: Esketamine
After anesthetic induction, an equal amount of saline is continuously infused by pump during the maintenance phase of anesthesia, and the saline infusion is stopped during suturing;
Drug: Normal Saline
After anesthesia induction, continue to administer esketamine by infusion at 0.1 mg/kg/h during the maintenance phase of anesthesia, and stop the infusion of esketamine during suturing.
After anesthetic induction, an equal amount of saline is continuously infused by pump during the maintenance phase of anesthesia, and the saline infusion is stopped during suturing;
Incidence of coughing during tracheal extubation
2 point scales; 0=None; 0 = Did not occur; 1 = Occurred;
Time frame: perioperative (From the awakening period to immediately after tracheal extubation)
Severity of coughing during tracheal extubation
4 grade scales; Grade 0: No choking cough; Grade 1: Single cough episode, considered mild choking cough; Grade 2: Intermittent cough, lasting less than 5 seconds, considered moderate choking cough; Grade 3: Continuous severe cough, lasting more than 5 seconds, considered severe choking cough. The higher the degree, the worse it is.
Time frame: perioperative (From the awakening period to immediately after tracheal extubation)
Agitation score during tube removal
3-level scale; 1: Awake and calm; 2: Mild agitation but can be comforted; 3: Moderate agitation, difficult to comfort; 4: Severe agitation, cannot be comforted; The higher the degree, the worse the situation.
Time frame: perioperative (From the awakening period to immediately after tracheal extubation)
Blood pressure
Baseline, post-induction, 1 minute after intubation, during suturing, at the end of surgery, 1 minute after extubation, 5 minutes after extubation
Time frame: From the induction period until 5 minutes after the completion of surgery
Airway pressure 5 minutes after intubation and at the end of surgery
Time frame: 5 minutes after intubation and at the end of the surgery
Intraoperative use rate and dosage of vasoactive drugs
Time frame: intraoperative (From the induction period to the end of anesthesia)
Sore throat score
4-point scales; 0 = None; 1 = Mild, milder than a common cold; 2 = Moderate, like a sore throat from a common cold; 3 = Severe, more severe than a common cold; The higher the score, the greater the level of pain.
Time frame: Baseline, Immediately postoperatively, 0.5 hours postoperatively, 2 hours postoperatively, 24 hours postoperatively, 48 hours postoperatively
Hoarseness scores
4-point scores; 0 = None; 1 = Transient hoarseness occurs; 2 = Patient perceives hoarseness during visit; 3 = Hoarseness is clearly noticeable; The higher the score, the more severe the hoarseness.
Time frame: Baseline, Immediately postoperatively, 0.5 hours postoperatively, 2 hours postoperatively, 24 hours postoperatively, 48 hours postoperatively
Surgical area pain scores
Pain NRS scale score: 0 = no pain; 1-3 = mild pain; 4-6 = moderate pain; 7-10 = severe pain. The higher the score, the more severe the pain.
Time frame: Postoperative day 1 and day 2
Incidence of adverse reactions within 48 hours postoperatively
Time frame: Within day 2 after surgery
Postoperative nausea and vomiting(PONV) score
Vomiting: 0 = None; 1 = Once; 2 = Twice; 3 = Three times or more Nausea, does it affect daily life: 0 = None; 1 = Sometimes; 2 = Often; 3 = Always
Time frame: Within day 2 after surgery
Postoperative analgesic dosage
Time frame: Within day 2 after surgery
Postoperative time to first food
Time frame: perioperative (Time from returning to the ward to the first food)
Upper Aerodigestive Symptoms After Thyroidectomy (UADS) questionnaire score
Upper Aerodigestive Symptoms After Thyroidectomy Questionnaire; Instructions: 0=No problem, 1=Minor, 2=Moderate, 3=Major. Voice symptoms 1. Vocal fatigue 2. Difficulty speaking loudly 3. Roughness 4. Voice in low pitch 5. Can"t speak in high pitch 6. Voice in high pitch Swallowing/pharyngeal symptoms 7. Burning during swallowing 8. Pharyngeal bolus 9. Pain during deglutition 10. Pharyngeal pain 11. Choking 12. Dry throat 13. Discomfort during swallowing 14. Throat clearing 15. Neck scar retraction during deglutition 16. Foreign body sensation in pharynx 17. Strangling sensation during swallowing 18. Coughing during swallowing 19. Foreign body in pharynx; The higher the score, the more severe it is.
Time frame: Three month after surgery
Heart rate
Baseline, post-induction, 1 minute after intubation, during suturing, at the end of surgery, 1 minute after extubation, 5 minutes after extubation
Time frame: Time Frame: From the induction period until 5 minutes after the completion of surgery
Oxygen saturation
Baseline, post-induction, 1 minute after intubation, during suturing, at the end of surgery, 1 minute after extubation, 5 minutes after extubation
Time frame: Time Frame: From the induction period until 5 minutes after the completion of surgery
Anesthesia time
Time frame: perioperative (Time from induction to discontinuation of anesthetic agents)
Surgery time
Time frame: From the start of surgery to the end of surgery
Extubation time
Time frame: perioperative (The time from discontinuation of anesthetic drugs to extubation)
Duration of tracheal tube placement
Time frame: perioperative (Time from intubation to )
Awakening time
Time frame: perioperative (Stop the anesthesia drug injection until awakening time)
Post-anesthesia care unit (PACU) stay time
Time frame: perioperative (Duration from entering the PACU to leaving the PACU)
PACU RASS score
* 4: Combative * 3: Very agitated * 2: Agitated * 1: Restless 0: Alert and calm * 1: Drowsy * 2: Light sedation * 3: Moderate sedation * 4: Deep sedation * 5: Unarousable
Time frame: perioperative (Record once every ten minutes from the time of entering the post-anesthesia care unit until leaving the recovery room.)
Intraoperative doses of propofol
Time frame: Intraoperative (From the induction period to the end of anesthesia)
Intraoperative doses of remifentanil
Time frame: Intraoperative (From the induction period to the end of anesthesia)
Intraoperative doses of Non-Steroidal Anti-Inflammatory Drugs(NSAIDs)
Time frame: Intraoperative (From the induction period to the end of anesthesia)
Intraoperative doses of sufentanil
Time frame: Intraoperative (From the induction period to the end of anesthesia)
Intraoperative fluid volume
Time frame: Intraoperative (From the induction period to the end of anesthesia)
Intraoperative blood loss
Time frame: Intraoperative (From the induction period to the end of anesthesia)
Sleep scores
4 point scores; 1 = Good sleep; 2 = Restless sleep; 3 = Dreamy sleep; 4 = Insomnia; The higher the score, the poorer the sleep.
Time frame: Postoperative 24 hours and 48 hours
Antiemetic drug dosage
Time frame: Within day 2 after surgery
Postoperative time to ambulation
Time frame: Perioperative (From the operating room to discharge)
Length of postoperative hospital stay
Time frame: Perioperative (From the operating room to discharge)
Postoperative time to first water intake
Time frame: Perioperative (Time from returning to the ward to the first drink of water)
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Jun 2026; primary completion for May 2027, 11 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Esketamine
The Second Hospital of Anhui Medical University