An interventional study of motor imagery with virtual reality and motor imagery alone in Complex Regional Pain Syndrome (CRPS) and Shoulder Hand Syndrome, sponsored by Green International University. Completed at 1 site in Pakistan. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-05-28.
Sponsored by Green International University · Not applicable, Interventional, and Treatment
the current study is a randomized controlled trial comparing the effectiveness of motor imagery techanique with and without virtual reality on pain intensity , functional disability and quality of life for individual with post stroke shoulder hand syndrome . this trial aims to evaluate pain , functional disability and overall quality of life . the primary outcome is pain reduction . while seconday outcome reduce disability and improve quality of life .the hypothesis is that the combination of motor imagery and virtual reality will result in significant greater clinical improvement compared to motor imagery alone .
Stroke continues to be one of the most common neurological causes of long term disability across the world. It often leads to a wide range of sensory, motor, and cognitive impairments that significantly reduce independence and quality of life. Among the various secondary complications that follow a stroke, Shoulder Hand Syndrome is considered one of the most painful and disabling conditions. It is described as a condition that presents with severe shoulder pain, hand edema, joint stiffness, reduced range of motion, and progressive functional decline. The condition is also known as Complex Regional Pain Syndrome Type One after stroke and it commonly develops within the first few months of the neurological injury. Estimates suggest that the condition affects between twelve to thirty percent of stroke survivors and is associated with marked disability if not treated in a timely and effective manner.Traditional physical therapy approaches such as range of motion exercises, manual therapy, strengthening, and functional task training remain the foundation of treatment. However, these interventions are often limited when patients experience severe pain or fear of movement, which prevents active participation. This has created a need for interventions that can stimulate the brain and support motor recovery without requiring significant physical effort or causing pain. One such approach is motor imagery. Motor imagery is described as the mental rehearsal of movement without any actual execution of the movement. During motor imagery practice, the individual imagines performing a movement as vividly as possible while staying in a relaxed state.hile traditional motor imagery has been widely studied, the use of virtual reality as an adjunct tool has expanded rapidly in recent years. Virtual reality based rehabilitation offers an immersive and engaging environment where the patient experiences visual and sensory feedback that closely resembles real movement. The use of virtual reality enhances motivation, increases concentration, and improves patient satisfaction during therapy sessions. Most importantly, virtual reality supports the activation of mirror neuron pathways and enhances sensory motor integration, which are critical components of recovery after a stroke.The intervention for both groups was delivered over a structured six week period. Each participant attended therapy three days per week, and every session last for a total of thirty minutes. This schedule is designed to provide consistent therapeutic exposure while preventing fatigue and allowing adequate recovery between sessions. By maintaining the same duration and frequency for both groups, the study ensured that any differences in outcomes can be attributed to the type of motor imagery intervention rather than differences in treatment time.
43 studies on the registry are indexed under Reflex Sympathetic Dystrophy; 4 are open to participants now.
This study's enrollment of 40 is below the median of 48 across 35 interventional studies indexed under Reflex Sympathetic Dystrophy.
Browse Reflex Sympathetic Dystrophy studies →Green International University is the lead sponsor of 17 studies on the registry; 1 is open to participants now.
Compared within Reflex Sympathetic Dystrophy, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Complex Regional Pain Syndromes. The counts are of registry records indexed under each term, refreshed daily. How we classify →
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Exclusion Criteria:
participants of shoulder hand syndrome received a combination treatment of motor imagery with virtual reality .both treatment options provided to improve motor function , reduce pain and improve quality of life . provide treatment of both motor imagery and virtual reality
Other: motor imagery with virtual reality
participant in this arm will receive only motor imagery treatment protocol . the therapy will target shoulder and hand region to increse ROM , decrease stiffness and pain .
Other: motor imagery alone
participants will receive 30 minute intervention session .the integrated components consist of motor imagery and virtual reality followed by the application of affected arease
participant will receive same 30 minutes session of specializes motor imagery techniques . no virtual reality sessions are included
PAIN INTENSITY
numeric pain rating scale is used to measure pain by rating one to ten according to the severity of the pain . scale level from 0 to 10 o means no pain 10 means higher level of pain
Time frame: three session per week for sic weeks
disability
shoulder pain and disability index (SPADI) use to measure level of disability at baseline and after intervention. the scale have scoring from 0 to 100 . 0 to 20 means mild shoulder pain and disability 21 to 40 means moderate shoulder pain and disability 41 to 60 means severe shoulder pain and disability 61 to 80 means very severe shoulder pain and disability 81 to 100 means extremely severe shoulder pain and disability
Time frame: three times a week for six week
Plan to share: Yes — only ipd used in the results publication will be shared
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
Time frame: it will be available after the completion of study
Access criteria: through the corresponding author
No publications or documents are linked to this record.
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Green International University