ClinicalTrials.gg
CompletedNCT07610889VR-SHSUpdated May 28, 2026

Effects of Motor Imagery Technique With and Without Virtual Reality on Pain Intensity ,Functional Disability and Quality of Life in Patient With Post Stroke Shoulder Hand Syndrome

An interventional study of motor imagery with virtual reality and motor imagery alone in Complex Regional Pain Syndrome (CRPS) and Shoulder Hand Syndrome, sponsored by Green International University. Completed at 1 site in Pakistan. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-05-28.

Primary conditionReflex Sympathetic DystrophyRegistry: Complex Regional Pain SyndromesReclassifiedWhy we changed it
Registry
Complex Regional Pain Syndromes — the first condition term the registry derived for this study.
ClinicalTrials.gg
Reflex Sympathetic Dystrophy
Why
  1. The study's listed conditions name Reflex Sympathetic Dystrophy, a narrower term within Complex Regional Pain Syndromes.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by Green International University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled Nov 2025, registered May 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
40 Years to 70 Years
Sex
All
01

Study summary

the current study is a randomized controlled trial comparing the effectiveness of motor imagery techanique with and without virtual reality on pain intensity , functional disability and quality of life for individual with post stroke shoulder hand syndrome . this trial aims to evaluate pain , functional disability and overall quality of life . the primary outcome is pain reduction . while seconday outcome reduce disability and improve quality of life .the hypothesis is that the combination of motor imagery and virtual reality will result in significant greater clinical improvement compared to motor imagery alone .

Read the detailed description

Stroke continues to be one of the most common neurological causes of long term disability across the world. It often leads to a wide range of sensory, motor, and cognitive impairments that significantly reduce independence and quality of life. Among the various secondary complications that follow a stroke, Shoulder Hand Syndrome is considered one of the most painful and disabling conditions. It is described as a condition that presents with severe shoulder pain, hand edema, joint stiffness, reduced range of motion, and progressive functional decline. The condition is also known as Complex Regional Pain Syndrome Type One after stroke and it commonly develops within the first few months of the neurological injury. Estimates suggest that the condition affects between twelve to thirty percent of stroke survivors and is associated with marked disability if not treated in a timely and effective manner.Traditional physical therapy approaches such as range of motion exercises, manual therapy, strengthening, and functional task training remain the foundation of treatment. However, these interventions are often limited when patients experience severe pain or fear of movement, which prevents active participation. This has created a need for interventions that can stimulate the brain and support motor recovery without requiring significant physical effort or causing pain. One such approach is motor imagery. Motor imagery is described as the mental rehearsal of movement without any actual execution of the movement. During motor imagery practice, the individual imagines performing a movement as vividly as possible while staying in a relaxed state.hile traditional motor imagery has been widely studied, the use of virtual reality as an adjunct tool has expanded rapidly in recent years. Virtual reality based rehabilitation offers an immersive and engaging environment where the patient experiences visual and sensory feedback that closely resembles real movement. The use of virtual reality enhances motivation, increases concentration, and improves patient satisfaction during therapy sessions. Most importantly, virtual reality supports the activation of mirror neuron pathways and enhances sensory motor integration, which are critical components of recovery after a stroke.The intervention for both groups was delivered over a structured six week period. Each participant attended therapy three days per week, and every session last for a total of thirty minutes. This schedule is designed to provide consistent therapeutic exposure while preventing fatigue and allowing adequate recovery between sessions. By maintaining the same duration and frequency for both groups, the study ensured that any differences in outcomes can be attributed to the type of motor imagery intervention rather than differences in treatment time.

02

Conditions studied

  • Complex Regional Pain Syndrome (CRPS)
  • Shoulder Hand Syndrome

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Keywords

  • motor imagery
  • virtual reality
  • shoulder hand syndrome
  • post stroke
  • physiotherapy
03

In context

Reflex Sympathetic Dystrophy Reclassified

43 studies on the registry are indexed under Reflex Sympathetic Dystrophy; 4 are open to participants now.

This study's enrollment of 40 is below the median of 48 across 35 interventional studies indexed under Reflex Sympathetic Dystrophy.

Browse Reflex Sympathetic Dystrophy studies →

Lead sponsor

Green International University is the lead sponsor of 17 studies on the registry; 1 is open to participants now.

Compared within Reflex Sympathetic Dystrophy, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Complex Regional Pain Syndromes. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
40 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Post-stroke patients diagnosed with Shoulder-Hand Syndrome
  • Age 40-70 years
  • Both males and females
  • Ability to understand motor imagery tasks
  • Duration of stroke ≥ 3 months

Exclusion criteria

Exclusion Criteria:

  • Cognitive impairment
  • Severe visual deficits
  • Psychiatric illness
  • Pain medication changes during study
  • Uncontrolled medical conditions
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Outcomes assessor)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Motor imagery with virtual reality

    participants of shoulder hand syndrome received a combination treatment of motor imagery with virtual reality .both treatment options provided to improve motor function , reduce pain and improve quality of life . provide treatment of both motor imagery and virtual reality

    Other: motor imagery with virtual reality

  • Active comparator
    motor imagery alone

    participant in this arm will receive only motor imagery treatment protocol . the therapy will target shoulder and hand region to increse ROM , decrease stiffness and pain .

    Other: motor imagery alone

Interventions

  • Othermotor imagery with virtual reality

    participants will receive 30 minute intervention session .the integrated components consist of motor imagery and virtual reality followed by the application of affected arease

  • Othermotor imagery alone

    participant will receive same 30 minutes session of specializes motor imagery techniques . no virtual reality sessions are included

06

What researchers measure

Primary outcomes

  1. PAIN INTENSITY

    numeric pain rating scale is used to measure pain by rating one to ten according to the severity of the pain . scale level from 0 to 10 o means no pain 10 means higher level of pain

    Time frame: three session per week for sic weeks

Other outcomes

  1. disability

    shoulder pain and disability index (SPADI) use to measure level of disability at baseline and after intervention. the scale have scoring from 0 to 100 . 0 to 20 means mild shoulder pain and disability 21 to 40 means moderate shoulder pain and disability 41 to 60 means severe shoulder pain and disability 61 to 80 means very severe shoulder pain and disability 81 to 100 means extremely severe shoulder pain and disability

    Time frame: three times a week for six week

07

Study locations

1 site
  • Green International Univeristy
    Lahore, Punjab Province 54000, Pakistan
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References and documents

Individual participant data

Plan to share: Yes — only ipd used in the results publication will be shared

Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report

Time frame: it will be available after the completion of study

Access criteria: through the corresponding author

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 28, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07610889
Lead sponsor
Green International University
Responsible party
Muhammad Hammad khan (principal investigator, Green International University) — Principal investigator
First posted
May 28, 2026
Start date
Nov 2, 2025
Primary completion
Apr 29, 2026
Completion
May 6, 2026
Last update
May 28, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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