An interventional study of Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit in Tooth Loss, sponsored by Tanta University. Enrolling by invitation at 1 site in Egypt. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2026-05-22.
Sponsored by Tanta University · Not applicable, Interventional, and Treatment
13 patients will be included in this study with a badly destructed upper molar indicated for extraction. Cone beam computerized tomography images revealed the presence of a large bone defect associated with oro-antral communication with the maxillary sinus. after extraction, The prefabricated allogenic scaffold will be seated. then 6 months later, implant will be inserted.
13 patients will be included in this study with a badly destructed upper molar indicated for extraction. Cone beam computerized tomography images revealed the presence of a large bone defect associated with oro-antral communication with the maxillary sinus. : Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit. After removal of tooth, oro-antral communication will be verified .The prefabricated CAD-CAM allogenic bone will be seated and covered with nonporous d-PTFE membrane which was secured with simple interrupted sutures. After 6 months, a new CBCT scan will be performed. A mucoperiosteal flap will be reflected ,and a bone biopsy will be taken using a trephine bur. Under strictly aseptic circumstances, the selected implant will be inserted
165 studies on the registry are indexed under Tooth Loss; 44 are open to participants now.
This study's planned enrollment of 13 is below the median of 30 across 120 interventional studies indexed under Tooth Loss.
Browse Tooth Loss studies →Tanta University is the lead sponsor of 1,010 studies on the registry; 321 are open to participants now.
Of its 15 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
a badly destructed upper molar indicated for extraction. Cone beam computerized tomography images revealed the presence of a large bone defect associated with oro-antral communication with the maxillary sinus. Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit. After removal of tooth, oro-antral communication will be verified .The prefabricated scaffold will be seated and covered with nonporous d-PTFE membrane. after 6 months, a bone biopsy will be taken using a trephine bur. Under strictly aseptic circumstances, the selected implant will be inserted.
Device: Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit
Extraction will be performed atraumatically using a piezotome surgical motor with an extraction kit. After removal of tooth, oro-antral communication will be verified .The prefabricated CAD-CAM Allogenic bone will be seated and covered with nonporous d-PTFE membrane
the integration of graft
CBCT
Time frame: 6 months
histological analysis of graft
histomorphometric analysis
Time frame: 6 months
Started Sep 2025 (actual). Primary completion is estimated for Oct 2026, 13 months after the start.
Of 71 non-industry interventional studies with no phase under Tooth Loss, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 48. This study's planned 13 months is below that.
Counting every sponsor, half of 77 studies reached it within 28 months; a quarter within 12 and three quarters within 48.
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