An observational study in Sleep Apnea Syndrome (OSAS), Central Sleep Apnea and Maxillomandibular Advancement Surgery, sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA). Not yet recruiting at 1 site in Netherlands. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Observational
Among 10 studies in Sleep Apnea Syndromes with a site in Netherlands — 4 open to participants now, 4 under way, none of them phase 3. Sleep Apnea Syndromes · Netherlands.
Among the 10 studies in Sleep Apnea Syndromes with a site in Netherlands, this one is one of 2 that started in 2026, is one of 5 observational ones, and was the 10th registered.
1,084 studies on the registry are indexed under Sleep Apnea Syndromes; 171 are open to participants now.
This study's planned enrollment of 60 is below the median of 150 across 343 observational studies indexed under Sleep Apnea Syndromes.
Browse Sleep Apnea Syndromes studies →4 of the 10 studies in Sleep Apnea Syndromes with a site in Netherlands are open now.
A study can be open while its sites in Netherlands have not opened yet or have stopped. Only those recruiting at a site in Netherlands →
Of the 117 Sleep Apnea Syndromes studies recruiting now, 57 (49%) set no upper age limit and 36 (31%) stop at 75 or younger; 24 take children under 18; 27 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →10 studies; the count open now beside each. This study's row is marked.
First in 2007; this study’s year is marked. 2 started in 2026.
Median enrollment 68 across the 5 interventional studies, 60 across the 5 observational. Of the 5 that completed or were terminated, 2 (40%) have results posted.
4 of 10 have an industry lead sponsor. The 7 most frequent:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) is the lead sponsor of 532 studies on the registry; 183 are open to participants now.
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) has 3 studies filed under Sleep Apnea Syndromes — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 10 studies in Sleep Apnea Syndromes with a site in Netherlands, from their registry updates:
Nothing recorded among them since 2026-09-25.
The goal of this observational prospective cohort study is to learn about the natural course of central and mixed sleep apneas that develop after maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) in adult patients.
The main question it aims to answer is:
Do central and mixed apneas resolve, partially resolve, or persist in the long term after MMA?
Participants will:
Undergo a first postoperative polysomnography (PSG) at 3-6 months after MMA (part of standard care).
Be invited into the study if central/mixed apneas are detected (CMAI% >25%). Undergo a second PSG at least 12 months after MMA (extra study procedure)
Obstructive sleep apnea (OSA) patients who are present with maxillomandibular advancement (MMA) treatment-related central and mixed apneas.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Apnea-hypopnea index (AHI)
Time frame: 12 months after MMA surgery
Central apnea index (CAI)
Time frame: 12 months after MMA surgery
Mixed apnea index (MAI)
Time frame: 12 months after MMA surgery
The percentage of central and mixed apneas of AHI (CMAI%)
Time frame: 12 months after MMA
Lowest oxyhemoglobin saturation (LSAT)
Time frame: 12 months after MMA surgery
Oxygen desaturation index (ODI)
Time frame: 12 months after MMA surgery
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Dec 2026; primary completion for Dec 2027, 12 months later.
Of 130 non-industry observational studies under Sleep Apnea Syndromes, half reached primary completion within 43 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 83. This study's planned 12 months is below that.
Counting every sponsor, half of 149 studies reached it within 43 months; a quarter within 15 and three quarters within 83.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) →