An interventional study of adapted physical activity in Brain Tumor Adult, sponsored by Center Eugene Marquis. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Center Eugene Marquis · Not applicable, Interventional, and Supportive care
The goal of this clinical trial is to assess the feasibility of an adapted physical activity (APA) program in adult patients (≥18 years) with primary brain tumors, regardless of tumor type, grade, treatment stage, or the presence of motor, sensory, attention, concentration, or memory deficits.
The main question it aims to answer is:
What is the effective adherence rate to an APA program among eligible patients with primary brain tumors?
Additional questions include:
Participants will:
2,440 studies on the registry are indexed under Brain Neoplasms; 540 are open to participants now.
This study's planned enrollment of 90 is above the median of 40 across 1,831 interventional studies indexed under Brain Neoplasms.
Browse Brain Neoplasms studies →Center Eugene Marquis is the lead sponsor of 32 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients unable to comply with the study schedule for social, medical, or psychological reasons.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients receive 2 strength exercise sheets to perform weekly at home + a recommendation to walk regularly (30 min/day). No supervised sessions. Activity is self-monitored via connected watch.
Other: adapted physical activity
Patients receive 1 strength exercise sheet to perform weekly at home + 1 hour of group training via videoconference per week. The videoconference session content matches the 2nd strength sheet from Arm 1. Activity is self-monitored via connected watch.
Other: adapted physical activity
Patients receive 1 strength exercise sheet to perform weekly at home + 1 hour of individualized and personalized training at home per week. The home session content matches the 2nd strength sheet from Arm 1. Activity is self-monitored via connected watch.
Other: adapted physical activity
Adapted Physical Activity (APA) is a tailored exercise program designed for individuals with specific health conditions, such as brain tumors. It aims to improve physical function, quality of life, and overall well-being while ensuring safety and feasibility. APA is supervised by trained professionals and adapted to each individual's abilities and needs.
Effective adherence rate to the Adapted Physical Activity program
The primary outcome is the proportion of eligible patients who participate in at least one Adapted Physical Activity session out of the total number of eligible patients solicited for inclusion. This metric Evaluates the feasibility of Adapted Physical Activity implementation in brain tumor patients.
Time frame: Baseline to 4 months
Adapted Physical Activity program observance rate
Evaluated through the number of sessions completed, the number of sessions reaching the recommended intensity level, and the duration of sessions performed during the 3-month supervised period and the 1-month autonomous period.
Time frame: Baseline to 4 months
Retention rate during the 3-month supervised Adapted Physical Activity period
Proportion of patients who complete the entire 3-month supervised APA program, reflecting their commitment and ability to sustain participation.
Time frame: Baseline to 3 months
Retention Rate After Supervised Adapted Physical Activity Period
Proportion of patients who continue Adapted Physical Activity beyond the initial 3-month supervised period, assessed at 4 months.
Time frame: 4 months
Reasons for early discontinuation of Adapted Physical Activity
Documentation of specific reasons (e.g., fatigue, disease progression, lack of motivation) for patients who discontinue Adapted Physical Activity prematurely
Time frame: Baseline to 4 months
Quality of life assessment using EORTC Quality of Life Questionnaire - Brain Neoplasm Module 20. Minimum value = 0, maximum value = 100. A higher score mean a worse outcome.
Evaluation of brain tumor-specific quality of life using the EORTC Quality of Life Questionnaire - Brain Neoplasm Module 20 questionnaire, which assesses symptoms and functional domains relevant to brain tumor patients
Time frame: Baseline, 3 months, and 4 months
Anxiety and depression assessment using Hospital Anxiety and Depression Scale questionnaire
Evaluation of anxiety and depression levels using the Hospital Anxiety and Depression Scale, a validated tool for assessing psychological distress. Minimum value = 0, maximum value = 21. A higher score mean a worse outcome.
Time frame: Baseline, 3 months, and 4 months
Fatigue assessment using Multidimensional Fatigue Inventory-20 questionnaire
Evaluation of multidimensional fatigue (general, physical, mental, reduced motivation, and reduced activity) using the Multidimensional Fatigue Inventory-20 questionnaire. Minimum value = 4, maximum value = 20. The higher the score, the greater the fatigue.
Time frame: Baseline, 3 months, and 4 months
Physical activity level assessment using International Physical Activity Questionnaire
Evaluation of physical activity intensity and frequency using the International Physical Activity Questionnaire, which classifies participants into low, moderate, or high activity levels. The higher the score, the higher the calculated energy expenditure.
Time frame: Baseline, 3 months, and 4 months
Motivation for physical activity assessment using Behavioral Regulation in Exercise Questionnaire - Version 2
Evaluation of motivation types (intrinsic, identified, introjected, external) using the Behavioral Regulation in Exercise Questionnaire - Version 2
Time frame: Baseline, 3 months, and 4 months
Perceived enjoyment of physical activity assessment using Physical Activity Enjoyment Scale questionnaire
Evaluation of enjoyment and satisfaction related to physical activity using the Physical Activity Enjoyment Scale questionnaire. Scoring range : 18 to 126 where higher scores indicate greater perceived enjoyment.
Time frame: Baseline, 3 months, and 4 months
Started Jul 2026 (actual). Primary completion is estimated for Jun 2028, 22 months after the start.
Of 306 non-industry interventional studies with no phase under Brain Neoplasms, half reached primary completion within 65 months of starting (the median), counting those still running; a quarter within 36 and three quarters within 125. This study's planned 22 months is below that.
Counting every sponsor, half of 317 studies reached it within 64 months; a quarter within 35 and three quarters within 125.
Start moved once since we started tracking on Sep 25, 2026: Jun 2026 → Jul 2026, on Oct 26, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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