An interventional study of transcranial random noise stimulation and sham stimulation in Healthy Adult Participants, sponsored by Adrian Guggisberg. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-28.
Sponsored by Adrian Guggisberg · Not applicable, Interventional, and Basic science
Language is an essential part of daily life, enabling us to communicate, understand others, read, and learn. Certain brain injuries can disrupt these abilities, and current treatments do not always lead to a full recovery. To improve future therapeutic approaches, it is necessary to better understand how the brain processes language and how its activity can be modulated.
This study aims to evaluate the effects of a non-invasive brain stimulation technique called transcranial random noise stimulation. This method involves applying a very weak electrical current to the scalp to modulate the activity of brain regions involved in language. It is commonly used in research and is considered safe when administered in accordance with current guidelines.
Healthy adult volunteers will participate in this study. Each participant will take part in two sessions spaced about a week apart. During one session, active stimulation will be used, and during the other, placebo stimulation will be used. Placebo stimulation resembles the actual stimulation but has no active effect. Neither the participants nor the researchers will know which type of stimulation is being used during each session.
During the sessions, participants will perform various language tasks, and their brain activity will be recorded using an electroencephalogram (EEG), a painless method.
This study does not provide any direct benefit to participants. The risks are low and limited to temporary sensations, such as a tingling sensation on the scalp. The results will provide a better understanding of how the brain processes language and could eventually contribute to the development of new rehabilitation approaches.
243 studies on the registry are indexed under Language; 76 are open to participants now.
This study's planned enrollment of 90 is above the median of 65 across 158 interventional studies indexed under Language.
Browse Language studies →Adrian Guggisberg is the lead sponsor of 5 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
to brain stimulation, such as
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
age 15-35 years
Device: transcranial random noise stimulation · Device: sham stimulation
age 60-90 years
Device: transcranial random noise stimulation · Device: sham stimulation
active HD-tRNS
current will be ramped up for 30 seconds and then switched of, to mimic the subjective sensation of tRNS.
Composite score
composite behavioural score reflecting overall language performance across four language domains (phonological, semantic, morphosyntactic, and reading)
Time frame: Periprocedural
Phonological processing
pseudoword reading task: accuracy (% correct) and response latency (ms)
Time frame: Periprocedural
Semantic processing
semantic fluency task: number of correct words produced within 1 min
Time frame: Periprocedural
Morphosyntactic processing
grammaticality judgment task: accuracy (% correct) and response latency (ms)
Time frame: Periprocedural
Reading speed
International reading speed test IReST: Reading time (s), words per minute, and error count
Time frame: Periprocedural
Sustained attention
d2-R: standard concentration performance score and error rate (control measure)
Time frame: Periprocedural
Plan to share: Yes — EEG and behavioral data
Time frame: After publication
Access criteria: Depository
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Adrian Guggisberg