An observational study in Catheter-Related Infections, Biofilms and Infection Prevention, sponsored by Centre Hospitalier Universitaire de Nīmes. Not yet recruiting at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-23.
Sponsored by Centre Hospitalier Universitaire de Nīmes · Observational
Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies.
The main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.
107 studies on the registry are indexed under Catheter-Related Infections; 16 are open to participants now.
This study's planned enrollment of 150 is below the median of 200 across 25 observational studies indexed under Catheter-Related Infections.
Browse Catheter-Related Infections studies →Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 587 studies on the registry; 96 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All central venous catheters (conventional, dialysis catheters, or PICC lines) that test positive for microorganisms.
Exclusion Criteria:
Other: Microbial analysis of catheter biofilm
Identification and sampling of the catheter, standard microbiological analysis, inclusion and transfer (INSERM platform), biofilm analysis, and collection of associated data (clinical, biological and related to the catheter).
Concentration (density) of viable bacterial biofilm
Measured in Colony Forming Units per millilitre (CFU/mL) for each compartment of the central venous catheter (internal and external lumen of the catheter)
Time frame: Baseline
Provide a descriptive analysis of the population of colonized or infected central venous catheters, including clinical, biological, and microbiological data.
* Causative microorganism (categorical outcome) * Catheter-related data (binary, numerical or categorical outcomes): catheter type, duration of catheterization (in days), time between admission and catheter placement (in days), insertion site, catheter rank * Type of infection (categorical outcome) : colonization, local infection, catheter-related sepsis, or catheter-related bacteremia * Associated conditions (binary or categorical outcomes): immunosuppression, diagnostic category, patient intubated or previously intubated (with overlap with the catheter being analyzed), patient on dialysis or previously on dialysis (with overlap with the catheter being analyzed), antibiotic therapy during the lifespan of the catheter being analyzed, parenteral nutrition during the lifespan of the catheter being analyzed.
Time frame: Baseline
Evaluate correlation between biofilm density and the following factors: microbiological, catheter-related, clinical, and patient-related.
See previous description of the outcomes
Time frame: Baseline
Evaluate correlation between the preferred location of biofilm and the following factors: microbiological, catheter-related, clinical, and patient-related.
See previous description of the outcomes
Time frame: Baseline
This study is not yet recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Nīmes