An interventional study of Root canal treatment in Intracanal Medicaments, Inflammatory Cytokines and Endodotic Microbiota, sponsored by Mansoura University. Active, not recruiting at 1 site in Egypt. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-16.
Sponsored by Mansoura University · Not applicable, Interventional, and Treatment
The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.
Mansoura University is the lead sponsor of 1,077 studies on the registry; 183 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
After biomechanical preparation of the canals, calcium hydroxide intracanal medicament will be placed inside the canal for one week before obturation.
Procedure: Root canal treatment
After biomechanical preparation of the canals, Ledermix intracanal medicament will be placed inside the canal for one week before obturation.
Procedure: Root canal treatment
After biomechanical preparation of the canals, Oleanolic acid intracanal medicament will be placed inside the canal for one week before obturation.
Procedure: Root canal treatment
Root canal treatments with administration of intracanal medicaments
Relief of signs and symptoms of apical periodontitis
Absence of discomfort with percussion, Absence of inflammatory exudate from the root canal.
Time frame: 1 Week
Decrease in bacterial count within the root canal.
A sample will be taken from the canal to assess the decrease in bacterial count inside the root canal by the effect of intracanal medicament.
Time frame: 1 week
Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues
A sample will be taken from the periapical region to detect the effect of the intracanal medicaments in reducing inflammation and promoting healing in the periapical region.
Time frame: 1 week
This study is active, not recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Mansoura University