An observational study in Acute Kidney Injury and Shock, sponsored by Fayoum University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-04.
Sponsored by Fayoum University · Observational
A study conducted to evaluate the effects of sodium profiling haemodialysis compared with conventional haemodialysis on hemodynamic tolerance and extravascular lung water in critically ill patients with AKI and shock.
A prospective comparative study was conducted on 120 ICU patients with AKI and shock and indicated for acute intermittent hemodialysis, divided into three groups of 40 patients each: Group 1: conventional hemodialysis, Group 2: linear sodium profiling, and Group 3: stepwise sodium profiling. Hemodynamic parameters, vasopressor requirements, lung ultrasound scores, and IVC measurements were assessed before, during, and after dialysis to evaluate the effects of sodium profiling haemodialysis compared with conventional haemodialysis on hemodynamic tolerance and extravascular lung water in critically ill patients with AKI and shock.
1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.
This study's enrollment of 120 is below the median of 150 across 773 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Fayoum University is the lead sponsor of 144 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with AKI and shock and indicated for acute intermittent hemodialysis that need vasopressor to maintain their mean blood pressure above 65 mmHg for ≥1-2 h before initiation of HD.
Adult Patients (18 years or older) who are admitted in ICU.
Exclusion Criteria:
Patients with hemodynamic instability who are not responsive to vasopressors and not candidate for intermittent hemodialysis.
conventional IHD group with fixed dialysate sodium of 140 mEq/L
stepwise sodium profiling group in which dialysate sodium was reduced in stages (150 → 145 → 140 → 135 mEq/L)
linear sodium profiling group in which dialysate sodium was Initiated at 150 mEq/L, linearly decreased to 135 mEq/L over the course of the dialysis session.
Mean Arterial Pressure (MAP) changes during the session
MAP is asessed pre dialysis, during dialysis and post dialysis to detect changes among the groups
Time frame: 2 to 3 hours
Vasopressor Requirement during the session
Vasopressor dose changes during the session among the groups
Time frame: 2 to 3 hours
Lung Ultrasound Score (LUS)
Changes in LUS Pre and Post-dialysis among the groups A score of \>15 generally suggests mild congestion, while values \>24 are considered indicative of moderate-to-severe pulmonary oedema or significantly increased EVLW.
Time frame: 4 to 6 hours
Ultrasonagraphic IVC Diameter
Changes in Ultrasonagraphic IVC Diameter pre and post-dialysis among the groups
Time frame: 4 to 6 hours
Ultrasonagraphic IVC Collapsibility
Changes in Ultrasonagraphic IVC Collapsibility pre and post-dialysis among the groups
Time frame: 4 to 6 hours
Dialysis Completion Rate
the ability to complete the session without haemodynamic instability
Time frame: 2 to 3 hours
Length of ICU Stay
Length of ICU Stay among the groups
Time frame: 4 to 15 days
Mortality
short term Mortality during ICU stay
Time frame: 4 to 15 days
Laboratory findings
Changes in serum sodium, Potassium, blood gases, urea and creatinine pre and post-dialysis among the groups
Time frame: 6 to 12 hours
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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Fayoum University