An observational study in Pulmonary Tuberculoses, Chronic Pulmonary Aspergillosis and Healthy Participants, sponsored by Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan. Active, not recruiting at 1 site in Uzbekistan. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-13.
Sponsored by Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan · Observational
The goal of the study is to determine whether vitamin D levels are associated with cytokine profiles in patients with pulmonary tuberculosis, including those with chronic pulmonary aspergillosis.
The main questions it aims to answer are:
Researchers will compare:
To see if differences in vitamin D levels are associated with variations in cytokine responses among these groups.
Participants will:
339 studies on the registry are indexed under Tuberculosis, Pulmonary; 69 are open to participants now.
This study's planned enrollment of 300 is close to the median of 300 across 86 observational studies indexed under Tuberculosis, Pulmonary.
Browse Tuberculosis, Pulmonary studies →Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan is the lead sponsor of 8 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants were recruited from specialized hospitals, including a national center for infectious diseases of Uzbekistan. The study population comprised patients receiving care for pulmonary tuberculosis, including those with coexisting chronic pulmonary aspergillosis, as well as healthy individuals from the local community.
Exclusion Criteria:
patients with active pulmonary tuberculosis before therapy
patients with active pulmonary tuberculosis with concomitant chronic pulmonary aspergillosis
individuals without any health issues
Correlation between serum 25-hydroxyvitamin D concentration and cytokine levels
To evaluate the correlation between serum 25-hydroxyvitamin D levels and circulating cytokine concentrations, including IL-1β, IL-4, IL-6, IL-8, IL-10, and TNF-α, in patients with active pulmonary tuberculosis with and without chronic pulmonary aspergillosis. 25-hydroxyvitamin D measurement: Serum concentration (ng/mL), measured using enzyme-linked immunosorbent assay (ELISA). Cytokine measurements: Serum concentrations (pg/mL) of IL-1β, IL-4, IL-6, IL-8, IL-10, and TNF-α, measured using multiplex immunoassay or ELISA. Statistical analysis: Correlation will be assessed using Pearson's or Spearman's correlation coefficient (r), depending on data distribution.
Time frame: At baseline (single time-point measurement at enrollment)
Prevalence of vitamin D deficiency
Prevalence of participants with vitamin D deficiency across study groups based on standard cut-off values.
Time frame: At baseline
Plan to share: No — Individual participant data will not be publicly shared due to concerns regarding patient confidentiality and the potential risk of identification. Additionally, data sharing is restricted by institutional and ethical regulations governing the use of clinical and laboratory data. De-identified data may be made available upon reasonable request to the corresponding author, subject to approval by the institutional review board and in accordance with applicable data protection policies.
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan