An interventional study of Thematic role and Sentence complexity in Developmental Language Disorder, sponsored by Father Flanagan's Boys' Home. Recruiting at 1 site in United States. Open to participants aged 5 Years to 7 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-06.
Sponsored by Father Flanagan's Boys' Home · Not applicable, Interventional, and Basic science
Millions of children - 7-12% of the school-age population - have developmental language disorder (DLD), a disorder that affects language learning, comprehension, and use. These children have difficulty with sentence production and comprehension at every stage of their development. These difficulties have major implications for the educational attainment of children with DLD compared to children with typical development (TD). Children with TD and adults make rapid predictions of upcoming words following verbs (e.g., predicting the patient in The dog eats the bone or the agent in The bone is eaten by the dog). Extensive work in children and adults indicates that prediction facilitates sentence comprehension by inducing a state of preparedness and contributes to language development by tuning the language system to the input. Children with DLD have a poorer ability to make sentence predictions, which may compound and result in sentence-comprehension deficits. Prior work on prediction deficits in DLD has focused on broad sentence characteristics like typicality or broad participant characteristics like vocabulary test scores. However, studies with typical individuals have identified more specific sentence- and participant-level contributors to sentence prediction. These factors have not been systematically explored in children with DLD. The investigators explore three separate hypotheses concerning factors that affect prediction in DLD. First, sentence- and participant-level properties affect prediction in children with DLD. Second, children with DLD lack robust representations of the underlying linguistic knowledge needed to predict, particularly abstract semantic features. Third, children with DLD have differences in event processing that relate to sentence prediction skill. The investigators investigate these hypotheses in 5-7-year-old school-age children with DLD across three Aims. Aim 1: Measure the effect of sentence- and participant-level properties on sentence prediction. The investigators will measure two participant-level cognitive factors (processing speed, verbal working memory) and their effect on prediction of agents and patients in sentences varying across two properties (syntactic complexity, semantic competition). Aim 2: Measure linguistic knowledge that underlies sentence prediction. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-\<round object>). Aim 3: Measure event-processing skills that underlie sentence prediction. The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes. Impact: This project has the promise to be highly impactful. First, it bridges disparate literatures on language processing in adults, children with TD, and children with DLD, providing clarity about predictive processing in DLD. Second, it may influence intervention approaches by identifying areas of strength and need in children with DLD. Third, it sets the stage for larger-scale longitudinal work examining effects of early prediction ability, language knowledge, and event processing on later sentence comprehension.
121 studies on the registry are indexed under Language Development Disorders; 49 are open to participants now.
This study's planned enrollment of 80 is close to the median of 74 across 106 interventional studies indexed under Language Development Disorders.
Browse Language Development Disorders studies →Father Flanagan's Boys' Home is the lead sponsor of 19 studies on the registry; 8 are open to participants now.
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The investigators will measure participant-level cognitive factors and their effect on prediction of agents and patients in sentences varying across syntactic complexity and semantic competition. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-\<round object\>). The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes.
Behavioral: Thematic role · Behavioral: Sentence complexity
The thematic role assessed for some trials will be the agent thematic role (i.e., the actor) and the thematic role assessed for the other trials will be the patient thematic role (i.e., the undergoer).
In half of the sentences, complexity will be simple (i.e., in simple active or passive sentences with no intervening linguistic material between the verb and the noun-to-be-predicted). In the other half of the sentences, complexity will be complex (i.e., additional linguistic material will intervene between the verb and the noun-to-be-predicted).
Behavioral response data
For verb knowledge tasks, the investigators will measure children's button presses for accuracy.
Time frame: During sessions for verb knowledge tasks
Eye tracking gaze data
During sentence processing and event processing, the investigators will measure children's looking to one or more images presented on-screen as a sentence is played (Aim 1) or as they point to images (Aim 3). The investigators will analyze how intervention conditions (thematic role and sentence complexity) influences children's looking patterns.
Time frame: During sessions for sentence processing and event processing tasks
Behavioral response data
For verb knowledge tasks, the investigators will measure children's button presses for latency.
Time frame: During sessions for verb knowledge tasks
PDFs hosted by the registry, ClinicalTrials.gov.
Started Feb 2026 (actual). Primary completion is estimated for Jul 2028, 29 months after the start.
Of 72 non-industry interventional studies with no phase under Language Development Disorders, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 57. This study's planned 29 months is close to that.
Counting every sponsor, half of 72 studies reached it within 30 months; a quarter within 19 and three quarters within 57.
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