ClinicalTrials.gg
RecruitingNCT07510854Updated Apr 6, 2026

Sentence Prediction in Developmental Language Disorder

An interventional study of Thematic role and Sentence complexity in Developmental Language Disorder, sponsored by Father Flanagan's Boys' Home. Recruiting at 1 site in United States. Open to participants aged 5 Years to 7 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-06.

Sponsored by Father Flanagan's Boys' Home · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Started Feb 2026; still recruiting 8 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Not applicable
Ages
5 Years to 7 Years
Sex
All
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Study summary

Millions of children - 7-12% of the school-age population - have developmental language disorder (DLD), a disorder that affects language learning, comprehension, and use. These children have difficulty with sentence production and comprehension at every stage of their development. These difficulties have major implications for the educational attainment of children with DLD compared to children with typical development (TD). Children with TD and adults make rapid predictions of upcoming words following verbs (e.g., predicting the patient in The dog eats the bone or the agent in The bone is eaten by the dog). Extensive work in children and adults indicates that prediction facilitates sentence comprehension by inducing a state of preparedness and contributes to language development by tuning the language system to the input. Children with DLD have a poorer ability to make sentence predictions, which may compound and result in sentence-comprehension deficits. Prior work on prediction deficits in DLD has focused on broad sentence characteristics like typicality or broad participant characteristics like vocabulary test scores. However, studies with typical individuals have identified more specific sentence- and participant-level contributors to sentence prediction. These factors have not been systematically explored in children with DLD. The investigators explore three separate hypotheses concerning factors that affect prediction in DLD. First, sentence- and participant-level properties affect prediction in children with DLD. Second, children with DLD lack robust representations of the underlying linguistic knowledge needed to predict, particularly abstract semantic features. Third, children with DLD have differences in event processing that relate to sentence prediction skill. The investigators investigate these hypotheses in 5-7-year-old school-age children with DLD across three Aims. Aim 1: Measure the effect of sentence- and participant-level properties on sentence prediction. The investigators will measure two participant-level cognitive factors (processing speed, verbal working memory) and their effect on prediction of agents and patients in sentences varying across two properties (syntactic complexity, semantic competition). Aim 2: Measure linguistic knowledge that underlies sentence prediction. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-\<round object>). Aim 3: Measure event-processing skills that underlie sentence prediction. The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes. Impact: This project has the promise to be highly impactful. First, it bridges disparate literatures on language processing in adults, children with TD, and children with DLD, providing clarity about predictive processing in DLD. Second, it may influence intervention approaches by identifying areas of strength and need in children with DLD. Third, it sets the stage for larger-scale longitudinal work examining effects of early prediction ability, language knowledge, and event processing on later sentence comprehension.

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Conditions studied

  • Developmental Language Disorder
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In context

Language Development Disorders

121 studies on the registry are indexed under Language Development Disorders; 49 are open to participants now.

This study's planned enrollment of 80 is close to the median of 74 across 106 interventional studies indexed under Language Development Disorders.

Browse Language Development Disorders studies →

Lead sponsor

Father Flanagan's Boys' Home is the lead sponsor of 19 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
5 Years to 7 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Pass a hearing screening at 25dB at 0.5, 1, 2, and 4 kHz
  • Have normal or corrected-to-normal vision
  • Have no history of neurological disorders
  • For DLD group, Test of Narrative Language 2 (TNL-2) score less than 92
  • For TD group, TNL-2 score greater than 92, a cut-off that provides excellent sensitivity/specificity (.92/.92).

Exclusion criteria

Exclusion Criteria:

  • Scores in the Autism range on the Childhood Autism Rating Scale 2 (CARS-2)
  • Scores below 75 on the Visual Spatial Index of the Wechsler Preschool and Primary Scale of Intelligence 4 (WPPSI-IV)
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
80 participants (estimated)

Study arms

  • Experimental
    Measure verb knowledge, sentence processing, and event processing

    The investigators will measure participant-level cognitive factors and their effect on prediction of agents and patients in sentences varying across syntactic complexity and semantic competition. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-\<round object\>). The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes.

    Behavioral: Thematic role · Behavioral: Sentence complexity

Interventions

  • BehavioralThematic role

    The thematic role assessed for some trials will be the agent thematic role (i.e., the actor) and the thematic role assessed for the other trials will be the patient thematic role (i.e., the undergoer).

  • BehavioralSentence complexity

    In half of the sentences, complexity will be simple (i.e., in simple active or passive sentences with no intervening linguistic material between the verb and the noun-to-be-predicted). In the other half of the sentences, complexity will be complex (i.e., additional linguistic material will intervene between the verb and the noun-to-be-predicted).

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What researchers measure

Primary outcomes

  1. Behavioral response data

    For verb knowledge tasks, the investigators will measure children's button presses for accuracy.

    Time frame: During sessions for verb knowledge tasks

  2. Eye tracking gaze data

    During sentence processing and event processing, the investigators will measure children's looking to one or more images presented on-screen as a sentence is played (Aim 1) or as they point to images (Aim 3). The investigators will analyze how intervention conditions (thematic role and sentence complexity) influences children's looking patterns.

    Time frame: During sessions for sentence processing and event processing tasks

Secondary outcomes

  1. Behavioral response data

    For verb knowledge tasks, the investigators will measure children's button presses for latency.

    Time frame: During sessions for verb knowledge tasks

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Study locations

1 of 1 sites recruiting
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References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Feb 2026 (actual). Primary completion is estimated for Jul 2028, 29 months after the start.

Of 72 non-industry interventional studies with no phase under Language Development Disorders, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 57. This study's planned 29 months is close to that.

Counting every sponsor, half of 72 studies reached it within 30 months; a quarter within 19 and three quarters within 57.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 24, 2026
First posted
Apr 6, 2026
StartActual
Feb 16, 2026
Primary completionEst.
Jul 2028
CompletionEst.
Jul 2028
Last update
Apr 6, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07510854
Lead sponsor
Father Flanagan's Boys' Home
Responsible party
Justin Kueser (Research Scientist, Father Flanagan's Boys' Home) — Principal investigator
First posted
Apr 6, 2026
Start date
Feb 16, 2026
Primary completion
Jul 2028 (estimated)
Completion
Jul 2028 (estimated)
Last update
Apr 6, 2026

Study contacts

Justin Kueser, PhD
Contact
justin.kueser@boystown.org
531-355-5035
Emma Kate Thome, PhD
Contact
emmakate.thome@boystown.org
531-355-5695

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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