ClinicalTrials.gg
CompletedNCT07498699CHESTUpdated Mar 27, 2026

Quantifying Changes in the Thoracic Wall After Nuss Bar Removal in Pectus Excavatum Patients Using 3D Imaging

An observational study in Pectus Excavatum, sponsored by Erik de Loos. Completed at 1 site in Netherlands. Per ClinicalTrials.gov, last updated 2026-03-27.

Sponsored by Erik de Loos · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
69
Sex
All
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Study summary

Pectus excavatum (funnel chest) is the most common congenital anterior thoracic wall deformity. It can be associated not only with cosmetic concerns but also with psychosocial and limiting somatic complaints. Patients with this condition are often treated surgically using the Nuss bar procedure, in which a metal bar is placed behind the sternum to effectively "pop out" the funnel chest. This bar typically remains in place for 2-3 years.

To analyze how the thoracic wall changes after removal of the Nuss bar, we aim to capture three-dimensional (3D) images at four different time points: just before removal, immediately after, and at 6 and 12 months post-removal. When significant changes over time are detected, we aim to identify factors that may predict retraction or recurrence. Based on these predictive factors, individualized decision-making regarding the timing of Nuss bar removal can be optimized to minimize the risk of retraction or recurrence.

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Conditions studied

  • Pectus Excavatum

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In context

Funnel Chest

79 studies on the registry are indexed under Funnel Chest; 10 are open to participants now.

This study's enrollment of 69 is close to the median of 68 across 32 observational studies indexed under Funnel Chest.

Browse Funnel Chest studies →

Lead sponsor

Erik de Loos is the lead sponsor of 3 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients with pectus excavatum who are visit our outpatient clinic and are scheduled for the removal of their Nuss bar.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients of all ages and genders with a Nuss bar eligible for removal.

Exclusion criteria

Exclusion Criteria:

  • Patients in whom the bar or stabilizing components were dislocated
  • Patients who underwent a second surgery for their pectus excavatum following the initial placement of the Nuss bar
  • Patients in whom retrosternal metal bars have been placed for any indication other than the treatment of pectus excavatum
  • Patients with connective tissue disorders such as Marfan syndrome
  • Patients diagnosed with epilepsy
  • Patients who are unable to maintain a stationary standing position for approximately 60 seconds
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
69 participants (actual)
Target follow-up
3 Months
Patient registry
Yes

Groups and cohorts

  • Postoperative 3D scans
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What researchers measure

Primary outcomes

  1. External Haller index

    Time frame: just before removal, immediately after, and at 6 and 12 months post-removal.

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Study locations

1 site
  • Zuyderland Medical Center
    Heerlen, Netherlands
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Sep 2020 to primary completion in Jan 2025, 51 months.

How these figures are worked out, and which studies are left out of them.

Registered
Mar 23, 2026
First posted
Mar 27, 2026
StartActual
Sep 16, 2020
Primary completionActual
Jan 6, 2025
CompletionActual
Jan 6, 2025
Last update
Mar 27, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Mar 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07498699
Lead sponsor
Erik de Loos
Responsible party
Erik de Loos (Thoracic surgeon, Zuyderland Medisch Centrum) — Sponsor-investigator
First posted
Mar 27, 2026
Start date
Sep 16, 2020
Primary completion
Jan 6, 2025
Completion
Jan 6, 2025
Last update
Mar 27, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

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