A Phase 3 interventional study of Transcranial Direct Current Stimulation and Transcranial Direct Current Stimulation in Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia and Aphasia Following Cerebral Infarction, sponsored by Dr. Ram Manohar Lohia Hospital. Not yet recruiting at 1 site in India. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-03-27.
Sponsored by Dr. Ram Manohar Lohia Hospital · Phase 3, Interventional, and Health services research
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other.
In aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, the studies have not focused on a particular type of deficit or stroke. Very few studies have focused on the impact of solely using tDCS. Very few studies have focused on acute to subacute strokes. The results of the studies have, nevertheless, been encouraging.
Improvements in aspects of language tested after a single session of tDCS are short-lived. There is an unmet need to probe the utility of repetitive tDCS on aspects of language function in patients who are aphasic due to acute stroke. There is also a paucity of data in the Indian scenario regarding the same.
338 studies on the registry are indexed under Aphasia; 95 are open to participants now.
This study's planned enrollment of 28 is close to the median of 30 across 298 interventional studies indexed under Aphasia.
Browse Aphasia studies →Dr. Ram Manohar Lohia Hospital is the lead sponsor of 9 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Will receive true Anodal tDCS
Device: Transcranial Direct Current Stimulation
Will receive Sham tDCS stimulation
Device: Transcranial Direct Current Stimulation
Anodal tDCS
Sham tDCS
Primary Outcome: Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 5 days
Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test
Time frame: at 5 days after tDCS
Co-Primary outcome: Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 5 days
Reaction times were documented in milliseconds.
Time frame: at 5 days after tDCS
Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 5 days
Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test.
Time frame: at 5 days after tDCS
Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 5 days
PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test
Time frame: at 5 days after tDCS
Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 4 weeks
Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test
Time frame: at 4 weeks after tDCS
Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 4 weeks
Reaction times were documented in milliseconds.
Time frame: at 4 weeks after tDCS
Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 4 weeks
Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test.
Time frame: at 4 weeks after tDCS
Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 4 weeks
PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test.
Time frame: at 4 weeks after tDCS
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Yes — IPD collected throughout the trial will be available from the Principle Investigator upon reasonable request.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Dr. Ram Manohar Lohia Hospital