An interventional study of Photon-counting CT (PCCT) and Ultrasound in Fatty Liver and Hepatic Steatosis, sponsored by Duke University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-03.
Sponsored by Duke University · Not applicable, Interventional, and Diagnostic
The purpose of this study is to see how well Photon Counting CT (PCCT) and ultrasound test results can find fat and scarring in the liver. They will be compared to MRI test results as the reference standard. Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study. They will also get an MRI, either on the same day or a different day, whichever is preferred. Participants will get an ultrasound on the same day as the MRI. If they have not had a hematocrit blood test in the past 24 hours, they will also receive one on the day of the CT scan.
1,451 studies on the registry are indexed under Fatty Liver; 292 are open to participants now.
This study's planned enrollment of 45 is below the median of 60 across 1,003 interventional studies indexed under Fatty Liver.
Browse Fatty Liver studies →Duke University is the lead sponsor of 2,025 studies on the registry; 275 are open to participants now.
Of its 194 completed or terminated interventional studies of FDA-regulated products, 159 (82%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study.
Diagnostic Test: Photon-counting CT (PCCT)
Participants will get an MRI, either on the same day as the PCCT scan or a different day, whichever is preferred.
Diagnostic Test: Magnetic Resonance Imaging (MRI)
Participants will get an ultrasound on the same day as the MRI.
Diagnostic Test: Ultrasound
Photon-counting computed tomography (PCCT) is a next-generation imaging technology using advanced detectors that directly count individual X-ray photons and measure their energy, rather than integrating total energy like traditional CT.
Ultrasound is a safe, radiation-free imaging technique using high-frequency sound waves to visualize soft tissues, organs, and blood flow in real-time.
MRI is a noninvasive, radiation-free medical imaging technique that uses powerful magnets and radio waves to generate detailed, high-resolution 3D images of soft tissues, organs, and bones.
Sensitivity of CT-FF (computed tomography fat fraction)
The percentage of patients with hepatic steatosis by MRI-PDFF who have positive CT-PDFF.
Time frame: 1 day to 14 days
Specificity of CT-FF (computed tomography fat fraction)
The percentage of patients without hepatic steatosis by MRI-PDFF who have negative CT-PDFF.
Time frame: 1 day to 14 days
Sensitivity of Ultrasound-Derived Fat Fraction (UDFF)
The percentage of patients with hepatic steatosis by MRI-PDFF who have positive UDFF.
Time frame: 1 day to 14 days
Specificity of Ultrasound-Derived Fat Fraction (UDFF)
The percentage of patients without hepatic steatosis by MRI-PDFF who have negative UDFF.
Time frame: 1 day to 14 days
Plan to share: No
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