An interventional study of Low Excision and High Suspension Hemorrhoidectomy and Conventional Milligan-Morgan Hemorrhoidectomy in Mixed Hemorrhoids, sponsored by The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine. Not yet recruiting. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-03-27.
Sponsored by The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine · Not applicable, Interventional, and Treatment
Low Excision and High Suspension Hemorrhoidectomy versus Conventional Milligan-Morgan Hemorrhoidectomy for Mixed Hemorrhoids
Participants Inclusion Criteria Age 18 to 70 years of age, both male and female; diagnosed with Goligher grade III or IV mixed hemorrhoids by anorectal physical examination; failure of conservative treatment for at least 3 months; voluntary participation in the study and written informed consent to complete the 12-month follow-up.
Exclusion Criteria Complicated with acute perianal abscess, anal fistula, anal fissure, inflammatory bowel disease, rectal prolapse, or anorectal malignancy; history of previous anorectal surgery; severe coagulation dysfunction, cardiopulmonary insufficiency, hepatic or renal failure, or mental disorders; pregnant or lactating women; inability to cooperate with postoperative follow-up and clinical evaluation.
Surgical Procedures Experimental Intervention: Low Excision and High Suspension Hemorrhoidectomy (LEHS) All procedures were performed under spinal or epidural anesthesia with patients in the lithotomy position by senior anorectal surgeons with at least 10 years of clinical experience. The intervention included four key steps: minimal excision of external hemorrhoidal tissue along the natural perianal skin crease with preservation of sufficient skin bridges and sensory tissue; full mobilization of internal hemorrhoidal mass from the rectal submucosal tissue to expose the intact base of the hemorrhoid pedicle; high figure-of-eight ligation of the pedicle base with 3-0 absorbable sutures followed by suspension and fixation of the ligated pedicle to the upper rectal wall for anal cushion anatomical restoration; partial closure of surgical wounds with absorbable sutures while maintaining adequate drainage to prevent hematoma and infection.
Comparator Intervention: Conventional Milligan-Morgan (MM) Hemorrhoidectomy The procedure was performed under the same anesthesia and position by the same surgical team as the LEHS group. Key steps included conventional V-shaped incision from the perianal skin to the dentate line with wide dissection and resection of external hemorrhoidal tissue; direct ligation of the internal hemorrhoid base with 3-0 silk sutures without prior mobilization or dissection, followed by radical resection of the distal hemorrhoidal tissue; preservation of skin bridges of at least 0.5 cm and natural open drainage for all surgical wounds without suture closure.
Outcome Measures 4.1 Primary Outcomes (1)Clinical effective rate of mixed hemorrhoids Description: Cured (complete resolution of clinical symptoms and hemorrhoid prolapse) plus improved (obvious relief of clinical symptoms) divided by the total number of patients; a clinical effective rate of at least 90% was defined as effective.
Time Frame: 12 weeks postoperatively (2)Hemorrhoid recurrence rate Description: Recurrence was defined as the reappearance of hemorrhoid prolapse or rectal bleeding that required clinical reintervention during the follow-up period.
Time Frame: 12 months postoperatively 4.2 Secondary Outcomes (1)Perioperative indicators Description: Assessment of operative time (minutes) and intraoperative blood loss (milliliters) during the surgical procedure.
Time Frame: Perioperatively (2) Postoperative pain score Description: Visual Analogue Scale (VAS, 0-10 points) to evaluate the degree of postoperative pain, with higher scores indicating more severe pain.
Time Frame: 6 hours postoperatively; 24 hours postoperatively; 72 hours postoperatively; 7 days postoperatively; 14 days postoperatively 4.3 Postoperative recovery parameters Description: Assessment of time to first defecation, wound healing time (days), and length of hospital stay (days) after surgery.
Time Frame: Up to 14 days postoperatively 4. 4 Postoperative complication rate Description: Recording of adverse events including perianal edema, urinary retention, secondary bleeding, wound infection, anal stenosis, and anal discomfort.
Time Frame: Up to 12 months postoperatively 4.5 Anorectal manometry parameters Description: Measurement of anal resting pressure (ARP), anal maximum squeeze pressure (AMSP), and rectal sensation threshold (RST) by anorectal manometry.
Time Frame: Baseline; 12 weeks postoperatively 4.6 Patient satisfaction score Description: 0-10 point subjective satisfaction score assessed by clinical questionnaire, with higher scores indicating higher patient satisfaction.
Time Frame: 12 months postoperatively
238 studies on the registry are indexed under Hemorrhoids; 73 are open to participants now.
This study's planned enrollment of 120 is above the median of 100 across 183 interventional studies indexed under Hemorrhoids.
Browse Hemorrhoids studies →The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine is the lead sponsor of 7 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:• Age 18-70 years, male or female;
Exclusion Criteria:• Combined with acute perianal abscess, anal fistula, anal fissure, inflammatory bowel disease, rectal prolapse, or anorectal ;
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Low Excision and High Suspension Hemorrhoidectomy
Procedure: Low Excision and High Suspension Hemorrhoidectomy
Conventional Milligan-Morgan Hemorrhoidectomy
Procedure: Conventional Milligan-Morgan Hemorrhoidectomy
Low Excision and High Suspension Hemorrhoidectomy
Conventional Milligan-Morgan Hemorrhoidectomy
Clinical effective rate at 12 weeks postoperatively
Cured (complete resolution of symptoms and hemorrhoid prolapse) + improved (obvious relief of clinical symptoms) / total number of patients; an effective rate ≥90% was defined as clinically effective.
Time frame: 12 weeks postoperatively
Hemorrhoid recurrence rate at 12 months postoperatively
Recurrence was defined as the reappearance of hemorrhoid prolapse or rectal bleeding requiring clinical reintervention during the follow-up period.
Time frame: 12 months postoperatively
No study locations are listed for this record.
Plan to share: No
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The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine