CClinicalTrials.gg
Not yet recruitingNCT07492043BREVIAUpdated Mar 25, 2026

Breast Tumour Size Measurement by Field Cycling Imaging

An observational study in Breast Cancer and Ductal Carcinoma In Situ, sponsored by University of Aberdeen. Not yet recruiting at 1 site in United Kingdom. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-25.

Sponsored by University of Aberdeen · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
12
Ages
18 Years and older
Sex
Female
01

Study summary

The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can accurately estimate tumour size in patients with a type of breast cancer called ductal carcinoma in situ (DCIS). The main question it aims to answer is:

Can FCI accurately estimate DCIS lesion size compared with histology results?

Participants will have a standard MRI scan and an FCI scan before undergoing surgery to remove the tumour.

02

Conditions studied

  • Breast Cancer
  • Ductal Carcinoma In Situ

Keywords

  • Field-Cycling Imaging
  • FCI
  • DCIS
  • Breast Cancer
03

In context

Breast Neoplasms

12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.

This study's planned enrollment of 12 is below the median of 184 across 2,642 observational studies indexed under Breast Neoplasms.

Browse Breast Neoplasms studies →

Lead sponsor

University of Aberdeen is the lead sponsor of 170 studies on the registry; 23 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Female patients from the Breast Unit of Aberdeen Royal Infirmary diagnosed with DCIS on clinical imaging with a breast tumour of at least 1 cm on imaging undergoing surgery.

Inclusion criteria

  • Females ≥ 18 years old.
  • Subjects diagnosed with DCIS on initial biopsy.
  • Lesion size >1 cm on imaging.
  • Subjects undergoing surgery as part of their treatment.
  • Able to fit comfortably in the scanners.
  • Able to understand written and spoken English.

Exclusion criteria

Exclusion Criteria:

  • Subjects undergoing chemotherapy or hormonal therapy.
  • Individuals unable to give informed consent.
  • Contra-indications to MRI scanning such as implantable cardiac devices.
  • Known allergy to contrast agent.
05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
12 participants (estimated)
Patient registry
No

Groups and cohorts

  • Breast Cancer

    Participants with breast cancer of ductal carcinoma in-situ (DCIS) who are due to undergo surgical treatment.

    Other: Field-Cycling Imaging research scan · Other: 3T MRI research scan

Interventions

  • OtherField-Cycling Imaging research scan

    Baseline FCI scan

  • Other3T MRI research scan

    Baseline MRI scan

06

What researchers measure

Primary outcomes

  1. Accuracy of DCIS lesion size estimation using FCI, validated against histopathological measurements (gold standard).

    Extent of agreement between lesion size estimation by FCI and actual lesion size according to NHS histopathology results.

    Time frame: Baseline

Secondary outcomes

  1. Comparison of DCIS lesion measurements using FCI and 3T MRI.

    Extent of agreement in lesion size measurements between FCI and conventional 3T MRI.

    Time frame: Baseline

07

Study locations

1 site
08

References and documents

Publications

  • Mallikourti V, Ross PJ, Maier O, Hanna K, Husain E, Davies GR, Lurie DJ, Lip G, Lahrech H, Masannat Y, Broche LM. Field cycling imaging to characterise breast cancer at low and ultra-low magnetic fields below 0.2 T. Commun Med (Lond). 2024 Oct 30;4(1):221. doi: 10.1038/s43856-024-00644-2. PubMed 39478081 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07492043
Lead sponsor
University of Aberdeen
Collaborators
NHS Grampian
Responsible party
Sponsor
First posted
Mar 25, 2026
Start date
Apr 2026 (estimated)
Primary completion
Dec 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Mar 25, 2026

Study contacts

Vasiliki Mallikourti, PhD
Contact
vasiliki.mallikourti@abdn.ac.uk
+44 1224 437831
Vasiliki Mallikourti, PhD
study chair · University of Aberdeen

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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