An observational study in Spinal Cord Neoplasms and Spinal Neoplasms, sponsored by Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria. Active, not recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-27.
Sponsored by Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria · Observational
Intradurale spinal tumors are rare neoplastic lesions that involve the spinal cord and surrounding structures and may cause neurological symptoms such as pain, motor deficits, sensory disturbances, and sphincter dysfunction. Surgical resection is often the primary treatment when feasible and may improve neurological outcomes and relieve spinal cord compression.
This retrospective observational study aims to analyze the epidemiological and clinical characteristics of patients who underwent surgical treatment for intradural spinal tumors at the Neurosurgery Unit of Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria between 2022 and 2024.
Clinical, radiological, and pathological data will be collected from electronic medical records, operative reports, and diagnostic imaging. The study will evaluate preoperative and postoperative neurological status using the McCormick functional scale, as well as postoperative complications and tumor recurrence.
The results of this study may contribute to improving the understanding of the clinical management of intradural spinal tumors and identifying factors associated with surgical outcomes and patient prognosis.
Intradural spinal tumors are uncommon neoplastic lesions involving the spinal cord and its surrounding structures. These tumors may be classified as intradural extramedullary or intramedullary depending on their origin and anatomical location. Although relatively rare, they represent an important clinical condition due to their potential to cause progressive neurological impairment, including pain, motor weakness, sensory deficits, and sphincter dysfunction.
Magnetic resonance imaging (MRI) represents the diagnostic gold standard for identifying and characterizing intradural spinal tumors. Surgical resection is generally considered the primary therapeutic option when feasible, with the aim of removing the lesion, decompressing the spinal cord, improving neurological symptoms, and obtaining a histological diagnosis. Advances in surgical techniques and intraoperative neurophysiological monitoring have contributed to improved surgical outcomes and postoperative recovery.
This study is a retrospective, single-center observational study conducted at the Neurosurgery Unit of the Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria, Italy. The study includes patients who underwent surgical treatment for intradural spinal tumors between 2022 and 2024.
Clinical data will be retrospectively collected from electronic medical records, surgical reports, imaging studies, and histopathological reports. The collected variables include demographic data, tumor characteristics (location and histology), clinical presentation, and postoperative outcomes.
The neurological functional status of patients will be evaluated using the McCormick functional scale, comparing preoperative and postoperative neurological conditions. Additional analyses will focus on postoperative complications and tumor recurrence.
The aim of this study is to provide a comprehensive description of the clinical and epidemiological characteristics of patients with intradural spinal tumors treated surgically at our institution and to contribute to a better understanding of the management and outcomes of this condition in clinical practice.
105 studies on the registry are indexed under Spinal Cord Neoplasms; 27 are open to participants now.
This study's enrollment of 50 is below the median of 150 across 31 observational studies indexed under Spinal Cord Neoplasms.
Browse Spinal Cord Neoplasms studies →Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria is the lead sponsor of 37 studies on the registry; 13 are open to participants now.
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Patients who underwent surgical treatment for intradural spinal tumors at the Neurosurgery Unit of Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria between 2022 and 2024. Clinical, radiological, histological, and postoperative outcome data were retrospectively collected from medical records.
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You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients who underwent surgical treatment for intradural spinal tumors at the Neurosurgery Unit of Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo di Alessandria between 2022 and 2024. Clinical, radiological, and histopathological data were collected retrospectively from medical records to evaluate patient characteristics, neurological outcomes, postoperative complications, and tumor recurrence.
Procedure: Surgical Resection of Intradural Spinal Tumors
This study consists of retrospective data collection and analysis of patients who underwent neurosurgical resection of intradural spinal tumors. No intervention is assigned as part of the study protocol.
Neurological Functional Outcome Assessed
Assessment of neurological functional status in patients undergoing surgical resection of intradural spinal tumors using the McCormick functional grading scale (Grade I: neurologically normal or mild deficit; Grade II: mild functional deficit, independent; Grade III: moderate deficit, limited independence; Grade IV: severe deficit, dependent; Grade V: paraplegia or quadriplegia). Preoperative and postoperative scores will be compared to evaluate changes in neurological function.
Time frame: From preoperative assessment to last available follow-up (up to 24 months post-surgery)
Postoperative Complications
Evaluation of postoperative complications, including hemorrhage, infections, dural fistula, and new neurological deficits, occurring after surgical treatment of intradural spinal tumors.
Time frame: From surgery to 30 days postoperatively
Plan to share: No
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Ran from Jan 2022 to primary completion in Dec 2024, 35 months.
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This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria