An observational study in Female Athletes, Anterior Cruciate Ligament Injuries and Athletic Performance, sponsored by Fu Jen Catholic University Hospital. Completed at 1 site in Taiwan. Open to female participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-09-02.
Sponsored by Fu Jen Catholic University Hospital · Observational
This prospective cohort study aims to investigate whether the mechanical properties of the anterior cruciate ligament (ACL) undergo measurable changes throughout a competitive basketball season in female collegiate athletes. Female athletes are at a significantly higher risk for non-contact ACL injuries compared to males. Beyond acute injuries, cumulative stress from high-intensity sports may lead to subclinical alterations in the ligament's biomechanical properties, potentially increasing injury risk.
Using non-invasive shear wave elastography (SWE) and countermovement jump (CMJ) tests, the study will monitor 60 elite players before and after the University Basketball League (UBL) season. The findings will help identify potential signs of cumulative loading and contribute to the development of early detection markers for injury risk in female athletes.
[Introduction and Rationale] The anterior cruciate ligament (ACL) is a critical stabilizer of the knee joint, particularly during high-demand athletic activities involving pivoting, rapid deceleration, and landing. Female athletes exhibit a significantly higher incidence (2 to 9 times) of non-contact ACL injuries compared to their male counterparts. While acute trauma is a well-recognized mechanism, emerging evidence suggests that cumulative loading over a competitive season may lead to subclinical alterations in the ligament's mechanical properties. These changes, such as decreased stiffness, may predispose athletes to injury by compromising joint stability and neuromuscular control. However, objective in vivo data regarding the seasonal adaptation of the ACL in elite athletes remains sparse.
[Study Design and Participants] This prospective cohort study will recruit 60 elite female collegiate basketball players from Division I teams of the University Basketball Association (UBA). The research is designed to track longitudinal changes in ACL integrity and functional performance across a full competitive season.
[Study Procedures]
Participants will undergo standardized assessments at two distinct time points:
Pre-season Assessment (Baseline): Conducted in October, prior to the start of the competitive UBL season.
Post-season Assessment: Conducted in April, following the conclusion of the competitive basketball season.
During each session, two primary modalities will be employed:
Imaging-based Assessment (Shear Wave Elastography):
Shear Wave Elastography (SWE) will be utilized to non-invasively quantify the mechanical properties of the ACL. The assessment will focus on:
Shear Wave Speed (m/s) Shear Modulus (kPa) These metrics serve as direct indicators of tissue stiffness and structural integrity. Measurements will be taken with the knee in a consistent, standardized position to ensure reproducibility.
Participants will perform Countermovement Jumps (CMJ) on KFORCE force plates to evaluate lower limb dynamic performance. This functional test provides insight into the athlete's neuromuscular status. Key variables collected will include:
Jump Height (cm) Reactive Strength Index (RSI): Calculated as the ratio of jump height to ground contact time.
Force Metrics: Including eccentric and concentric impulse to analyze force production and absorption strategies.
[Research Goal] By integrating imaging-based mechanical data with functional biomechanical outcomes, this study seeks to identify potential "fatigue" markers or adaptive responses in the ACL resulting from seasonal athletic demands. The findings aim to bridge the gap between clinical imaging and athletic performance, ultimately informing individualized injury prevention strategies and early detection protocols for female athletes at risk.
625 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 192 are open to participants now.
This study's enrollment of 60 is below the median of 98 across 153 observational studies indexed under Anterior Cruciate Ligament Injuries.
Browse Anterior Cruciate Ligament Injuries studies →Fu Jen Catholic University Hospital is the lead sponsor of 33 studies on the registry; 18 are open to participants now.
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Elite female collegiate basketball teams
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Exclusion Criteria:
ACL Shear Modulus
The shear modulus of the anterior cruciate ligament (ACL) will be measured using shear wave elastography (SWE). This value serves as a quantitative indicator of ligament tissue stiffness.
Time frame: Baseline and at the end of the competitive season (approximately 6 months)
ACL Shear Wave Speed
The velocity of shear waves propagating through the ACL tissue, measured via SWE. This value is used to evaluate the structural integrity and density of the ligament tissue.
Time frame: Baseline and at the end of the competitive season (approximately 6 months)
Reactive Strength Index (RSI)
Calculated as the ratio of jump height to ground contact time (RSI = jump height / ground contact time) during a countermovement jump (CMJ). This index evaluates the explosive power and neuromuscular control of the lower limbs.
Time frame: Baseline and at the end of the competitive season (approximately 6 months)
Countermovement Jump (CMJ) Height
The maximum vertical displacement of the center of mass during a countermovement jump, measured using KFORCE force plates.
Time frame: Baseline and at the end of the competitive season (approximately 6 months)
Ran from Sep 2025 to primary completion in Apr 2026, 7 months.
Of 73 non-industry observational studies under Anterior Cruciate Ligament Injuries, half reached primary completion within 36 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 167. This study's 7 months is below that.
Counting every sponsor, half of 82 studies reached it within 37 months; a quarter within 13 and three quarters within 76.
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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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