CClinicalTrials.gg
Not yet recruitingNCT07468825TIPAUpdated Mar 13, 2026

Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder

An observational study in Alcohol Use Disorder and Cognition Disorders, sponsored by Assistance Publique - Hôpitaux de Paris. Not yet recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-13.

Sponsored by Assistance Publique - Hôpitaux de Paris · Observational

From the registry’s dates

  • Primary completion was expected by Apr 2026, 6 months ago, but the record still lists the study as not yet recruiting.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
30
Ages
18 Years and older
Sex
All
01

Study summary

Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to uncertainty and adapt their behavior.

This study aims to better understand how personal characteristics such as anxiety, self-esteem, sensitivity to reward and punishment, perfectionism, and cognitive abilities may influence adaptation processes in individuals with AUD.

Participants receiving usual care at Paul Brousse Hospital will be invited to take part in a single experimental session lasting about 45 minutes. During this session, they will complete:

  • A computerized learning task in which they respond to visual stimuli and receive feedback on their performance
  • Standardized questionnaires assessing psychological traits and cognitive functioning

The learning task is designed to evaluate how participants adjust their behavior when the rules of the task change unexpectedly. Researchers will measure how performance changes in response to uncertainty and examine how these changes relate to individual psychological characteristics.

This research does not modify participants' medical care and involves no medication or invasive procedures.

By improving understanding of the cognitive and behavioral mechanisms involved in Alcohol Use Disorder, the study may help advance scientific knowledge about how individuals adapt to uncertainty and inform future research in addiction and mental health.

Read the detailed description

Alcohol Use Disorder (AUD) is associated with difficulties in decision-making and behavioral adaptation, particularly in situations involving uncertainty. Individual psychological traits may influence how people with AUD adjust their behavior when facing changing environments, but this relationship remains insufficiently understood.

This monocentric, non-interventional study aims to explore how individual traits influence adaptive processes in adults diagnosed with Alcohol Use Disorder.

Participants receiving usual care at Paul Brousse Hospital will attend a single experimental session lasting approximately 45 minutes. During this session, they will perform a computerized learning task designed to evaluate behavioral adaptation when task rules change unexpectedly. They will also complete standardized questionnaires assessing personality traits and cognitive functioning.

Behavioral performance during the task will be analyzed to measure adaptation to uncertainty and examined in relation to individual psychological characteristics.

The study does not involve medication, medical devices, or any modification of clinical care.

02

Conditions studied

  • Alcohol Use Disorder
  • Cognition Disorders

Keywords

  • Alcohol Use Disorder
  • Addictive Behaviors
  • Decision Making
  • Cognitive Adaptation
  • Behavioral Flexibility
  • Uncertainty Processing
  • Exploration-Exploitation Tradeoff
  • Neurocognitive Processes
  • Personality Traits
  • Psychological Assessment
  • Computerized Cognitive Task
03

In context

Alcoholism

1,606 studies on the registry are indexed under Alcoholism; 329 are open to participants now.

This study's planned enrollment of 30 is below the median of 180 across 173 observational studies indexed under Alcoholism.

Browse Alcoholism studies →

Lead sponsor

Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Adult patients diagnosed with Alcohol Use Disorder (DSM-5) receiving outpatient care in the Psychiatry and Addiction Department

Inclusion criteria

  • Adults aged 18 years or older
  • Patients receiving care for Alcohol Use Disorder at the Psychiatry and Addiction Unit of Paul Brousse Hospital
  • No objection to participation in the study

Exclusion criteria

Exclusion Criteria:

  • Diagnosed neurological disorder
  • Patient covered by State Medical Assistance (AME)
  • Individuals under legal protection measures (guardianship, curatorship, or legal safeguard)
  • Individuals deprived of liberty by judicial or administrative decision
  • Pregnant or breastfeeding women
  • Psychiatric disorders that could compromise proper study participation (excluding Alcohol Use Disorder)
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
30 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Uncertainty Cost Index During Behavioral Adaptation Task

    Uncertainty cost index. Exploration-exploitation behaviors are inferred from the percentage of correct responses obtained during the CHEAT phase of the computerized task. For each participant, the difference in accuracy rate between the end of the learning phase and the beginning of the CHEAT phase is calculated. This difference (Δ) defines the uncertainty cost index and reflects exploratory behavioral responses to the introduction of misleading feedback.

    Time frame: At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)

Secondary outcomes

  1. Correlation Between Uncertainty Cost Index and Psychometric Trait Scores

    Correlation coefficient between the uncertainty cost index and standardized psychometric test scores assessing personality traits and cognitive characteristics.

    Time frame: During the single study session (approximately 45 minutes)

07

Study locations

1 site
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07468825
Lead sponsor
Assistance Publique - Hôpitaux de Paris
Responsible party
Sponsor
First posted
Mar 13, 2026
Start date
Apr 1, 2026 (estimated)
Primary completion
Apr 1, 2026 (estimated)
Completion
Apr 1, 2027 (estimated)
Last update
Mar 13, 2026

Study contacts

Catherine MARTELLI, Dr
Contact
catherine.martelli@aphp.fr
145593372 ext. +33

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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