An observational study in Hirschsprung Disease, sponsored by University Hospital, Angers. Not yet recruiting. Open to participants aged Up to 16 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by University Hospital, Angers · Observational
Hirschsprung disease (HD) is a rare congenital disorder of the enteric nervous system, affecting approximately 1 in 5,000 live births. It is characterized by the absence of ganglion cells in the distal colon, leading to functional intestinal obstruction due to impaired peristalsis. Surgical treatment consists of resection of the aganglionic segment-most commonly rectosigmoid-followed by a colo-rectal, colo-anal, or ileo-anal anastomosis.
Among colo-anal pull-through procedures, the Swenson technique was historically performed through an exclusively transanal approach, which carries a risk of sphincter injury correlated with operative duration. More recently, combined laparoscopic and transanal approaches have been developed to reduce this risk, although they may be associated with higher overall complication and reoperation rates.
The Swenson procedure can be performed using a single-port laparoscopic approach, a technique that is sparsely described in the literature and rarely practiced in France. Single-port laparoscopy represents an emerging surgical technique that, despite increased technical complexity for surgeons, may further enhance postoperative recovery and cosmetic outcomes compared to conventional multiport laparoscopy.
The objective of this study is to describe the outcomes of single-port laparoscopic Swenson pull-through in children with Hirschsprung disease and to compare them with outcomes obtained using more conventional approaches, namely exclusive transanal surgery or combined multiport laparoscopic and transanal approaches.
66 studies on the registry are indexed under Hirschsprung Disease; 23 are open to participants now.
This study's planned enrollment of 70 is below the median of 300 across 32 observational studies indexed under Hirschsprung Disease.
Browse Hirschsprung Disease studies →University Hospital, Angers is the lead sponsor of 464 studies on the registry; 116 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Children under 16 years of age with diagnosis of Hirschsprung disease confirmed by initial rectal biopsy and postoperative pathological examination
Exclusion criteria
Swenson coloanal pullthrough with single incision laparoscopy
Procedure: transanal or laparoscopy assisted Swenson coloanal pullthrough
Swenson coloanal pullthrough with conventional (multiport) laparoscopy
Procedure: transanal or laparoscopy assisted Swenson coloanal pullthrough
Swenson coloanal pullthrough with exclusive trananal approach
TA-Swenson consist of total trananal endorectal pullthrough after a short submucosal dissection of the last part of the rectum. Laparoscopy-assisted Swenson pull-through consists of laparoscopic mobilization of the aganglionic colon with intraoperative level confirmation, followed by a transanal resection of the aganglionic segment and a primary coloanal anastomosis
To compare the short-term effectiveness of different surgical laparoscopic approaches used for the Swenson technique.
Short-term effectiveness, defined as spontaneous bowel transit without obstructive-spectrum events during the first postoperative year, including: * Constipation * Delayed resumption of oral feeding * Sphincter hypertonicity * Hirschsprung-associated enterocolitis
Time frame: From surgery to 12 months postoperatively
To compare intraoperativensurgical efficiency according to surgical approach
Surgical efficiency, defined as operative time for coloanal anastomosis completion without conversion, including the approach for intraoperative frozen-section biopsy.
Time frame: During surgery (day 0)
To compare immediate postoperative recovery
Recovery, defined as hospital discharge in good health, which includes: * Return of bowel function * Resumption of oral feeding * Absence of early postoperative complications, particularly infectious complications (surgical site infection, intra-abdominal infection, sepsis)
Time frame: At hospital discharge (average 5 days)
Short-term complications
All early postoperative complications graded according to the Clavien-Madadi classification
Time frame: From hospital discharge to 30 days after surgery
Long-term complications
All late postoperative complications graded according to the Clavien-Madadi classification
Time frame: From 31 days after surgery up to the last clinical follow-up visit (mean follow-up: 5.5 years)
Long-term continence outcomes
Assessed using the Krickenbeck score, which includes: * Bowel movements perception * Soining (graded 0 - absence to 3 - constant/social prolem) * Constipation (graded from 0 - absence to 3 - resistant to diet and laxatives)
Time frame: Assessed after toilet training age (≥3-4 years old) and up to the last clinical follow-up visit (mean follow-up: 5.5 years)
No study locations are listed for this record.
This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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University Hospital, Angers