An interventional study of FamilyCHESS and Standard of Care in Opioid Use Disorder, Opioid Use Disorder, Moderate and Opioid Use Disorder, Severe, sponsored by University of Wisconsin, Madison. Not yet recruiting at 2 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-07.
Sponsored by University of Wisconsin, Madison · Not applicable, Interventional, and Treatment
The purpose of this clinical trial is to develop and test whether a text- and web-based tool called FamilyCHESS - designed for individuals with opioid use disorder (OUD) and a concerned significant other (CSO) - can help the identified patient (IP) begin and stay on medication for opioid use disorder (MOUD).
1,411 studies on the registry are indexed under Opioid-Related Disorders; 290 are open to participants now.
This study's planned enrollment of 338 is above the median of 63 across 1,123 interventional studies indexed under Opioid-Related Disorders.
Browse Opioid-Related Disorders studies →University of Wisconsin, Madison is the lead sponsor of 1,161 studies on the registry; 182 are open to participants now.
Of its 151 completed or terminated interventional studies of FDA-regulated products, 114 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participant dyads will receive FamilyCHESS
Behavioral: FamilyCHESS
Participant dyads will receive standard of care treatment for MOUD
Behavioral: Standard of Care
Participants will have access to the FamilyCHESS system on their personal smartphone. FamilyCHESS incorporates Invitation to Change (ITC), a combination of Community Reinforcement and Family Training (CRAFT), Acceptance and Commitment Therapy (ACT), and Motivational Interviewing (MI) training principles and components for a CSO (e.g., parent, spouse/romantic partner, adult child, other family member or friend) to encourage and support the patient to engage in treatment.
Participants will receive links to Substance Abuse and Mental Health Services Administration (SAMHSA) resources for MOUD
Initiation of MOUD
Number of days between study start date and MOUD initiation date.
Time frame: 12 months
Continuity on MOUD
Collected through self-report. Percentage of days IPs in the intervention arm are on MOUD compared to control arm.
Time frame: 4, 8, and 12 months
Change in IP Quality of Life
Quality of life (QOL) is measured using the SF-12 Health Survey, which is a 12-item questionnaire. It is scored on a variable Likert scale. Scores range from 12 to 47 where higher scores indicate greater quality of life.
Time frame: Baseline, 4, 8, and 12 months
Change in number of opioid overdoses
IPs will self-report whether, and how many, overdoses they experienced in the previous 30 days. An opioid overdose occurs when someone turns blue, has little or no breathing, or passes out and cannot be woken up without help after using opioids.
Time frame: Baseline, 4, 8, and 12 months
Change in number of emergency room visits
Time frame: Baseline to 12 months
Change in percentage of days of opioid use
IPs will self-report the number of days they used any illegal/street drugs, abuse any prescription medications, or drink alcohol over the previous 30 days. It will be reported as a percentage of overall days of use
Time frame: Baseline, 4, 8, and 12 months
Change in McMaster Family Functioning Scale (FAD-GF)
FAD-GF is a 12 item questionnaire using a 4-point Likert scale. 1 = strongly agree and 4 = strongly disagree. Odd items are reverse scored. Once the odd items have been reverse scored the participant's family functioning score is the sum of the 12 items, which ranges from 12-48, where higher scores indicate better family functioning.
Time frame: Baseline, 4, 8, and 12 months
Change in CSO coping styles
CSOs will complete a 30-item survey about coping strategies. It is scored on a 3-point Likert scale where no = 0 and often = 3. Scores range from 0-90, where higher scores indicate better coping strategies.
Time frame: Baseline, 4, 8, and 12 months
Change in CSO perceptions of social support
Using the Alcohol, Drugs and the Family Support Scale, CSOs will rate their perception of social support. The scale is a 25 item survey which uses a 3-point Likert scale where 0 = never and 3 = often (some items are reverse scored). Scores range from 0-75. Higher scores indicate greater sense of support.
Time frame: Baseline, 4, 8, and 12 months
Change in CSO Quality of Life
QOL is measured using the SF-12 Health Survey, which is a 12-item questionnaire. It is scored on a variable Likert scale. Scores range from 12 to 47 where higher scores indicate greater quality of life.
Time frame: Baseline, 4, 8, and 12 months
Plan to share: Yes
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This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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University of Wisconsin, Madison