An interventional study of Electronic Health Record alert in Referral and Consultation, Glomerulonephritis and Hematuria, sponsored by Geisinger Clinic. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by Geisinger Clinic · Not applicable, Interventional, and Screening
The purpose of the study is to evaluate prospectively the impact of an electronic health record (EHR) alert on primary care providers' (PCP) referral to Nephrology of Geisinger patients with high risk signs (blood and protein in the urine) of glomerulonephritis. This will help quantify the relative effectiveness of EHR alerts on PCPs' referral patterns.
Adult patients receiving care from a Geisinger PCP within 2 years from the start of the study who underwent urinalysis and had high-risk glomerulonephritis features (positive test results for hematuria and proteinuria) will participate in the study. Patients will be randomized 1:1 at the patient level, to intervention arm or usual care arm. The Geisinger primary care provider caring for the participating patient will then, based on the patient's randomization status, receive or not receive one-time EHR alert that will fire during patient clinic visit prompting referral to Nephrology. Index date is the date of the PCP visit during which the EHR alert will fire. The analysis plan will evaluate the potential impact of EHR alert. The primary outcome will be proportion of adult patients with high-risk features for glomerulonephritis with a nephrology referral order within 1 month of the PCP visit.
Exploratory outcomes will include:
Analyses will employ Generalized Linear Mixed Model to evaluate the intervention effect on the primary outcome, after adjusting for patient-level and provider-level characteristics as fixed-effects and allowing for dependencies of patient-level observations within providers by incorporating these as hierarchical random-effects.
115 studies on the registry are indexed under Glomerulonephritis; 32 are open to participants now.
This study's planned enrollment of 1,200 is above the median of 50 across 87 interventional studies indexed under Glomerulonephritis.
Browse Glomerulonephritis studies →Geisinger Clinic is the lead sponsor of 127 studies on the registry; 17 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 7 (78%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
GFR and eGFR (kidney filtering)
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Electronic Health Record alert
Patient will receive usual care
The EHR alert will open upon logging into patient's chart. It will display relevant information about hematuria (dipstick blood), urine microscopy (if available), proteinuria (ACR, PCR, dipstick protein), most recent (if ever) nephrology visit, and most recent (if ever) urology visit. The EHR alert will provide a preselected order button for a nephrology referral with the indication pre-filled out. It will also provide options to order confirmatory urinalysis with microscopy testing and an option to refer to urology. The provider will have an option to deselect the nephrology referral, which will prompt reasons for not ordering the referral: "Not appropriate"; "already seeing a nephrologist"; "palliative care"; "patient refuses"; "Other (document)". The alert will not be a hard-stop in the chart.
Referral to Nephrology
Proportion of adult patients with high-risk features for glomerulonephritis with a nephrology referral order
Time frame: Within One month of index PCP visit
3-6 month Nephrology referral
Proportion of patients with nephrology referral order within 3 and 6 months of index PCP visit
Time frame: Within 3 and 6 months of index PCP visit
Nephrology referral completion
Proportion of patients with completed nephrology appointment within 3 and 6 months of index PCP visit
Time frame: Within 3 and 6 months of index PCP visit
Time to referral to nephrology
Compare the median time to referral between the intervention and usual care group
Time frame: Within 12 months of index PCP visit
Quantitative albuminuria or proteinuria testing
Compare the proportion of patients with dipstick hematuria and concomitant proteinuria (2+ or 3+) who underwent quantitative albuminuria or proteinuria testing (albumin/creatinine ratio or protein/creatinine ratio or 24-hour urine albumin or protein) within 6 months of index PCP visit
Time frame: Within 6 months of index PCP visit
Repeat urinalysis
Proportion of patients who completed repeat urinalysis and microscopy lab test within 6 months of index PCP visit
Time frame: Within 6 months of index PCP visit
Time from PCP referral to scheduled nephrology visit
Compare time from PCP referral to the date of nephrology appointment during follow up period
Time frame: Within 12 months of index PCP visit
Proportion that undergo kidney biopsy and median time to kidney biopsy
Compare the proportion of patients referred to nephrologists who undergo a kidney biopsy and time to kidney biopsy between the intervention and usual care group within 12 months of index PCP visit
Time frame: Within 12 months of index PCP visit
Proportion diagnosed with glomerulonephritis
Proportion of patients who were diagnosed with a glomerulonephritis during follow up period
Time frame: Within 12 months of index PCP visit
Plan to share: Undecided — We will consider sharing data upon reasonable request, pending data use agreements.
No publications or documents are linked to this record.
Start is estimated for Nov 2026; primary completion for Dec 2027, 13 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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