An interventional study of automated instant message-guided neuropsychiatric symptoms management and general mental health management in Mild Cognitive Impairment (MCI), sponsored by The University of Hong Kong. Recruiting at 1 site in Hong Kong. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-05-18.
Sponsored by The University of Hong Kong · Not applicable, Interventional, and Supportive care
This study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment to reduce their NPS, and to investigate the feasibility and effectiveness of the intervention.
Message contents:
The message content library will consist of four parts: 1.orientation, 2. brief mild cognitive impairment education messages, 3. acceptance and commitment therapy messages, 4.booster message.
Message delivery
Control Group:
The control group will receive instant messages about mental health management from GovHK website (https://www.gov.hk/en/residents/health/mental/), which is open to the public.
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's planned enrollment of 160 is above the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →The University of Hong Kong is the lead sponsor of 1,262 studies on the registry; 340 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants in intervention group will receive the EMI for 9 weeks. Based on the steps of mobile message development recommended by Abroms, et al., our multidisciplinary team - including a neurologist, nurses, clinical psychologists and gerontologists - will develop an ACT message content library and protocol for IM delivery (i.e. EMI).
Behavioral: automated instant message-guided neuropsychiatric symptoms management
The control group will receive instant messages about general mental health management from the HKSAR Government website in 9 weeks, which is open to the public (https://www.shallwetalk.hk/en/mental-well-being/mental-well-being-is-related-to-you/), with reminder text messages of follow-up surveys.
Behavioral: general mental health management
Participants in intervention group will receive the EMI for 9 weeks. Based on the steps of mobile message development recommended by Abroms, et al., we will develop a message content library and protocol for EMI delivery.
Participants in control group will receive the messages for 9 weeks. The control group will receive instant messages about general mental health management from the HKSAR Government website, which is open to the public (https://www.shallwetalk.hk/en/mental-well-being/mental-well-being-is-related-to-you/), with reminder text messages of follow-up surveys.
MBI-C scores
The primary outcome will be MBI-C scores to assess NPSs. A higher MBI-C scores will indicate a higher level of neuropsychiatric symptoms.
Time frame: at baseline, 10th week and 24th week
Depressive symptoms (PHQ-9)
Each item was scored on a 4-point scale (0 "not at all" to 3 "nearly every day"). The total score is calculated by summing up the score of all items (range 0-27). High scores indicate worse depressive symptoms.
Time frame: at baseline, 10th week and 24th week
Anxiety symptoms (GAD-7)
A 7-item scale with score ranging from 0 to 21, higher scores indicate higher severity of anxiety symptom
Time frame: at baseline, 10th week and 24th week
Quality of life (EuroQol 5-dimension 5-level questionnaire [EQ-5D-5L])
The EQ-5D-5L assesses five health dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, each rated on five levels of severity, with scores ranging from -0.864 to 1, where higher scores indicate better quality of life. Additionally, it includes a visual analogue scale (VAS), ranging from 0 (the worst health imaginable) to 100 (the best health imaginable).
Time frame: at baseline, 10th week and 24th week
Cognitive functions (HK-MoCA)
The total score is calculated by summing up the score of all items. Higher scores indicate better cognitive function.
Time frame: at baseline, 10th week and 24th week
Acceptance of negative emotions and valued-based actions (AAQ-II)
AAQ-II is a measure of psychological flexibility. Each item is rated on a 7-point scale from 1 = never true to 7 = always true. Scores range from 1-49. A lower score indicates a lower level of psychological flexibility.
Time frame: at baseline, 10th week and 24th week
Subjective Cognitive Decline scale (SCD-9)
SCD-9 is a scale detecting subjective cognitive function. Higher socre indicate worse subjective cognitive function.
Time frame: at baseline, 10th week and 24th week
Plan to share: No
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