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Not yet recruitingNCT07413263Updated Feb 18, 2026

Impact of Tyrosine Kinase Inhibitors on Glucose Level and Lipid Metabolism in Chronic Myeloid Leukemia Patients

An observational study in Chronic Myeloid Leukemia, sponsored by Assiut University. Not yet recruiting. Per ClinicalTrials.gov, last updated 2026-02-18.

Sponsored by Assiut University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
75
Sex
All
01

Study summary

to known the impact of drugs that used in CML pt as TKIs on glucose and lipid metabolism

Read the detailed description

to known the impact of drugs that used in CML pt as TKIs on glucose and lipid metabolism and how danger they drugs be

02

Conditions studied

  • Chronic Myeloid Leukemia
03

In context

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

964 studies on the registry are indexed under Leukemia, Myelogenous, Chronic, BCR-ABL Positive; 109 are open to participants now.

This study's planned enrollment of 75 is below the median of 141 across 149 observational studies indexed under Leukemia, Myelogenous, Chronic, BCR-ABL Positive.

Browse Leukemia, Myelogenous, Chronic, BCR-ABL Positive studies →

Lead sponsor

Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

CML patients

Inclusion criteria

  • CML patients free medical history

Exclusion criteria

Exclusion Criteria:

  • diabetic
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
75 participants (estimated)
Patient registry
No

Interventions

  • DrugTyrosine kinase Inhibitors (Imatinib & Nilotinib)

    these drugs used in CML only

06

What researchers measure

Primary outcomes

  1. Change in HbA1c levels in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors

    Assessment of change in HbA1c levels in CML patients treated with TKIs.

    Time frame: Baseline and 3, 6, 9, and 12 months

Secondary outcomes

  1. Change in lipid profile in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors

    Assessment of changes in lipid profile including total cholesterol, triglycerides, LDL, and HDL in CML patients treated with TKIs.

    Time frame: Baseline and 3, 6, 9, and 12 months

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Hwang SM, Im SH, Rudra D. Signaling networks controlling ID and E protein activity in T cell differentiation and function. Front Immunol. 2022 Aug 2;13:964581. doi: 10.3389/fimmu.2022.964581. eCollection 2022. PubMed 35983065 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07413263
Lead sponsor
Assiut University
Responsible party
Nancy Atef Abdou Mousa (Resident Doctor of Internal Medicine, Assiut University) — Principal investigator
First posted
Feb 17, 2026
Start date
May 1, 2026 (estimated)
Primary completion
Dec 30, 2027 (estimated)
Completion
Dec 30, 2028 (estimated)
Last update
Feb 18, 2026

Study contacts

Nancy Atef Abdou, doctor
Contact
nancyatef918@gamil.com
01027607363 ext. 01153253658
mai mostafa kamal, prof
Contact
Mona mohamed soliman, prof
principal investigator · Assiut University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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