A Phase 3 interventional study of Dexamethasone 4 Mg/mL Injectable Solution and Dexamethasone 8Mg Solution for Injection in Postoperative Pain, sponsored by Oman Ministry of Health. Recruiting at 1 site in Oman. Open to participants aged 21 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-03-30.
Sponsored by Oman Ministry of Health · Phase 3, Interventional, and Treatment
This study aims to compare the effectiveness of 4mg and 8mg dexamethasone administered submucosally in reducing postoperative pain after dental implant surgery. Participants will be randomly assigned to receive either 4mg dexamethasone, 8mg dexamethasone, or a placebo (normal saline) at the surgical site.
Later, postoperative pain will be assessed using a Visual Analog Scale at 6 hours after the surgery and daily for the next 6 days. Also the number of pain-relief tablets consumed after the surgery will be recorded.
Preoperative anxiety will be assessed using Generalized Anxiety Disorder-7 (GAD-7) questionnaire to assess its association with postoperative pain scores.
The results of this study will help determine the optimal dose of dexamethasone that is effective for postoperative pain control following dental implant surgery.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
This study's planned enrollment of 138 is above the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Oman Ministry of Health is the lead sponsor of 18 studies on the registry; 12 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
8mg/2ml dexamethasone injection.
Drug: Dexamethasone 8Mg Solution for Injection
4mg/1ml Dexamethasone ampoule + 1ml of sterile normal saline for injection. Mixing dexamethasone with sterile normal saline for injection is considered safe and has no effect on drug potency and efficacy based on current evidence.
Drug: Dexamethasone 4 Mg/mL Injectable Solution
2 ml of sterile normal saline for injection.
Drug: Saline (NaCl 0,9 %) (placebo)
Drug page: Dexamethasone
Syringe will be concealed. Submucosal injection will be adjacent to the surgical site in the buccal vestibule
Syringe will be concealed. Submucosal injection will be adjacent to the surgical site in the buccal vestibule
Syringe will be concealed. Submucosal injection will be adjacent to the surgical site in the buccal vestibule
Postoperative pain assessed using Visual Analog Scale (VAS)
Postoperative pain will be assessed using a 10-cm visual analog scale in patients following single dental implant surgery after submucosal administration of dexamethasone or placebo
Time frame: at 6 hours postoperatively and then once daily for the following 6 days
Number of postoperative analgesic tablets consumed
The total number of rescue analgesic tablets consumed postoperatively will be recorded daily following the implant surgery
Time frame: Postoperatively for 7 days
Correlation between preoperative anxiety (GAD-7) and postoperative pain score
Anxiety will be assessed preoperatively using Generalized Anxiety Disorder-7 questionnaire. The relationship between preoperative anxiety scores and postoperative VAS following dental implant surgery will evaluated.
Time frame: Anxiety will be assessed preoperatively on the day of the surgery before implant placement
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Studies of the drug tested here: Dexamethasone
Oman Ministry of Health