An interventional study of ReproEVO intervention in Anterior Cruciate Ligament Rupture With Ligamentoplasty, sponsored by University Hospital, Brest. Not yet recruiting at 3 sites in France. Open to participants aged 15 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-02-05.
Sponsored by University Hospital, Brest · Not applicable, Interventional, and Other
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%.
During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.
Athletes can thus be classified as plastic or rigid . Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%. Although the number of studies on the subject is growing, there is currently no consensus on rehabilitation protocols.
During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.
We have demonstrated that athletes and athletes after ACL reconstruction show variability in the integration of proprioceptive information during a complex balance task.
Athletes can thus be classified as plastic (able to vary the source of proprioceptive information depending on conditions) or rigid (unable to do so).
Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.
University Hospital, Brest is the lead sponsor of 594 studies on the registry; 135 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients with Anterior Cruciate Ligament (ACL) rupture scheduled for ACL reconstruction surgery
Procedure: ReproEVO intervention
After the inclusion visit, each assessment will include an examination of standing balance in two support conditions: hard floor or soft floor and two conditions of vibration of the Achilles tendons or lumbar muscles, performed randomly over five trials for each condition. The subjects stand with their eyes covered by an opaque mask. Vibrators are positioned at both locations and vibrated randomly after a trial without recording to perceive the destabilizing effect induced by the vibration. The data is recorded using a force platform on the floor. Subjects will be seated and strapped into a rigid device attached to their leg. The device is connected to a motor that maintains a constant speed. Maximum strength will be measured at two different speeds. Finally, at each assessment, the subjects will complete questionnaires about their fear of pain, their assessment of their knee's capabilities, and the activities they engage in.
Assessment of progress in proprioceptive reweighting after knee ligament reconstruction
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
Time frame: Baseline, 3 months after surgery and 9 months after surgery
Assesment of the variation in weighting between before and after the operation
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
Time frame: Baseline and 3 months postoperatively
Assess postural control
Difference in the size of the shift in the center of pressure in a static standing position, with eyes open and closed
Time frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score (0 : Not at all sure; 10: Completely safe) at the inclusion visit (preoperative); at 3 months postoperatively and at 9 months postoperatively
Time frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess the subjective IKDC activity score
Assess the subjective IKDC activity score (0: Never; 10: Always) at the inclusion visit (preoperative); at 3 months postoperatively and at 9 months postoperatively.
Time frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Plan to share: Yes — All collected data that underlie results in a publication
Supporting information: Study protocol
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University Hospital, Brest