An interventional study of Melatonin 5 mg and Melatonin 10 mg in Pain Management, Pain After Surgery and Cesarean Section Pain, sponsored by Benha University. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by Benha University · Not applicable, Interventional, and Supportive care
The goal of this clinical trial is to learn if melatonin will decrease pain after C.S. The main questions it aims to answer are:
Does melatonin lower the number of times participants need to use a rescue analgesia? What medical problems do participants have when taking melatonin? Researchers will compare different doses of melatonin to see the ideal dose to decrease pain after C.S.
Participants will:
Take melatonin 30 min before C.S and will be observed for 24 hours for pain and consumption of other analgesia
1,190 studies on the registry are indexed under Agnosia; 508 are open to participants now.
This study's enrollment of 60 is below the median of 78 across 1,024 interventional studies indexed under Agnosia.
Browse Agnosia studies →Benha University is the lead sponsor of 356 studies on the registry; 68 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Drug: Melatonin 5 mg
Drug: Melatonin 10 mg
Drug: Placebo
Group I: (5 mg melatonin): Participants will receive 5 mg of oral melatonin 1 hours before the cesarean section.
Group II: (10 mg melatonin): Participants will receive 10 mg of oral melatonin 1 hours before the cesarean section.
Group III: (Placebo): Participants will receive an identical placebo tablet 1 hours before the cesarean section.
Postoperative pain intensity measured using the VAS (Visual Analogue Scale)
it typically consists of a 100 mm straight line with descriptive anchors at each end representing the extremes of the sensation (for example, "no pain" at one end and "the most severe pain imaginable" at the other). Respondents indicate their experience by marking a point on the line, and the distance from the lower anchor is measured and recorded as a continuous variable
Time frame: 2, 6, 12, and 24 hours post-surgery.
first rescue analgesia
Time to first request for analgesia postoperatively
Time frame: the first 24 hours post operative
Total opioid consumption
amount of opioid requested by the patient
Time frame: the first 24 hours post operative
Incidence of adverse effects
such as nausea, vomiting, headache, dizziness, sedation
Time frame: first 24 hours post operative
Time to first ambulation post-surgery
first movement by the patient
Time frame: first 24 hours post operative
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Benha University