An interventional study of Injectable Platelet-Rich Fibrin (i-PRF). and Scaling and Root Planing (SRP). in Periodontitis, Periodontal Pocket and Alveolar Bone Loss, sponsored by Al-Mustansiriyah University. Completed at 1 site in Iraq. Open to participants aged 30 Years and older. Per ClinicalTrials.gov, last updated 2026-10-07.
Sponsored by Al-Mustansiriyah University · Not applicable, Interventional, and Treatment
This study aims to evaluate the clinical and microbiological effects of using injectable Platelet-Rich Fibrin (i-PRF) as an adjunct to non-surgical periodontal therapy (scaling and root planing) in patients with periodontitis. The study uses a split-mouth design where one side of the mouth receives the treatment with i-PRF and the other side receives standard treatment alone. Clinical parameters and bacterial counts will be compared at baseline, 1 month, and 3 months after intervention .
Patients with periodontitis will be recruited for this split-mouth randomized controlled trial. All participants will receive full-mouth supra and sub-gingival scaling and root planing (SRP). In the intervention side, i-PRF will be injected into the periodontal pockets, while the control side will receive SRP only.
Clinical measurements including Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), and Bleeding on Probing (BOP) will be recorded. Additionally, microbiological samples will be collected to assess the changes in the subgingival Porphyromonas gingivalis and Fusobacterium nucleatum . Follow-up visits are scheduled at 1 and 3 months post-intervention to assess the adjunctive benefit of i-PRF.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 18 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Al-Mustansiriyah University is the lead sponsor of 31 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
This quadrant of the mouth will receive full-mouth scaling and root planing (SRP) followed by the subgingival injection of injectable Platelet-Rich Fibrin (i-PRF) into the periodontal pockets
Biological: Injectable Platelet-Rich Fibrin (i-PRF). · Procedure: Scaling and Root Planing (SRP).
This contralateral quadrant of the mouth will receive full-mouth scaling and root planing (SRP) only, serving as the control side to compare with the i-PRF intervention.
Procedure: Scaling and Root Planing (SRP).
Ten ml of whole blood is collected from the participant into plain tubes and immediately centrifuged. The centrifugation protocol follows the low-speed concept (e.g., 700 rpm for 3 minutes). The upper orange-colored liquid (i-PRF) is then collected and injected subgingivally into the periodontal pockets using a 25-gauge needle immediately after scaling and root planing
Also known as: Autologous Platelet Concentrate., i-PRF
Full-mouth non-surgical periodontal therapy including supra and sub-gingival scaling and root planing performed using ultrasonic devices and Gracey curettes to remove dental biofilm and calculus
Also known as: Non surgical periodontal therapy, SRP, Initial periodontal therapy, Phase I periodontal therapy, Cause related periodontal therapy
Change in Probing Pocket Depth (PPD)
Probing pocket depth will be measured in millimeters from the gingival margin to the base of the periodontal pocket using a standardized periodontal probe (e.g., William's probe) at six sites per tooth.
Time frame: Baseline, 1 month, and 3 months post-intervention
Clinical Attachment Level (CAL)
Measurement of the distance from the cemento-enamel junction (CEJ) to the base of the periodontal pocket in millimeters.
Time frame: Baseline, 1 month, and 3 months post-intervention
Bleeding on Probing (BOP)
Assessment of the presence or absence of bleeding within 30 seconds after probing, recorded as a percentage of total sites.
Time frame: Baseline, 1 month, and 3 months post intervention
Plaque Index (PI)
Assessment of the amount of dental plaque on the tooth surfaces to evaluate the patient's oral hygiene during the study.
Time frame: Baseline, 1 month, and 3 months post intervention .
Microbiological Analysis (Bacterial Load)
Quantification of subgingival periodontal pathogens (P. gingivalis and F. nucleatum )using Quantitative Real-time PCR (qPCR) from subgingival plaque samples.
Time frame: Baseline, 1 month, and 3 months post intervention
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Al-Mustansiriyah University