An interventional study of Selective Lesion Curettage and Cyanoacrylate Tissue Adhesive and Complete Periapical Lesion Curettage and Suturing in Healing and Patient Related Outcomes, sponsored by Mansoura University. Active, not recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-20.
Sponsored by Mansoura University · Not applicable, Interventional, and Treatment
The goal of this randomized clinical trial is to determine whether selective curettage combined with cyanoacrylate tissue adhesive improves clinical outcomes in endodontic microsurgery compared with the conventional approach. The study purpose is to evaluate the postoperative healing associated with this conservative surgical protocol.
The main questions it aims to answer are:
Does selective curettage with tissue adhesive reduce postoperative pain, swelling, and complications compared to complete curettage with suturing?
How does selective curettage affect clinical and radiographic healing of persistent periapical lesions?
Researchers compared complete lesion curettage with suturing to selective curettage (40-70% lesion removal) with cyanoacrylate tissue adhesive closure to assess differences in healing and patient-related outcomes.
Participants :
Underwent endodontic microsurgery using one of the two surgical protocols Attended follow-up visits at 1, 3, and 7 days for clinical evaluation of pain, swelling ,Discomfort , Bleeding , Local reaction and Wound Dehiscence
Attended follow-up visits at 3, 6, and 12 months for clinical and radiographic evaluation of periapical healing using 2D radiographs and CBCT
Mansoura University is the lead sponsor of 1,077 studies on the registry; 183 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
patients underwent conventional endodontic microsurgery with complete removal of the periapical lesion followed by flap repositioning and closure using sutures.
Procedure: Complete Periapical Lesion Curettage and Suturing
Patients underwent endodontic microsurgery with selective removal of approximately 40-70% of the periapical lesion, followed by flap closure using cyanoacrylate tissue adhesive without sutures.
Procedure: Selective Lesion Curettage and Cyanoacrylate Tissue Adhesive
Selective curettage is a conservative approach to treat periapical lesions by removing part of the granulomatous tissue while avoiding complications and damage to the neighboring structures. It also provides the least traumatic approach with minimal post-operative complications. It had an additional advantage, which is providing tissue samples for biopsy of the lesion, especially in cases where there was a diagnostic dilemma regarding its origin . In the selective curettage technique, approximately 50-70% of the granulomatous tissue was removed while preserving the portion in close proximity to critical areas, followed by standard root-end resection and retrofilling then Clinical and radiographic assessments, including CBCT, for bone healing assesment .
Complete Periapical Lesion Curettage and Suturing is a conventional endodontic microsurgical procedure performed to manage persistent periapical pathology following root canal treatment. After administration of local anesthesia, a full-thickness mucoperiosteal flap is elevated to expose the periapical region. The periapical lesion is completely curetted and removed, followed by apical root-end resection. A retrograde cavity is prepared using ultrasonic tips and sealed with a biocompatible root-end filling material. Hemostasis is achieved, and the surgical flap is repositioned and stabilized using conventional sutures. This approach represents the standard surgical protocol for endodontic microsurgery and serves as the active comparator in this study.
Pain intensity
Pain intensity is assessed using the Visual Analogue Scale (VAS, 0-10)
Time frame: (1st, 3rd, and 7th day post-operative)
Swelling
Presence of swelling is assessed clinically by visual inspection and physical examination and recorded as a binary outcome (present / absent)
Time frame: 1st, 3rd, and 7th day post-operative
Bleeding
Post-operative bleeding presence is assessed as a binary outcome (Yes / No)
Time frame: 1st, 3rd, and 7th day post-operative
Radiographic Bone healing
Radiographic bone healing is assessed using standardized periapical radiographs (2D) and cone beam computed tomography (CBCT, 3D)
Time frame: 3, 6 , and 12 months
Plan to share: No
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Mansoura University