CClinicalTrials.gg
CompletedNCT07349992Updated Jan 20, 2026

Retrograde Intrarenal Surgery (RIRS) With High-Power Laser and Flexible, Navigable Suction Access Sheath (FANS) vs Mini-Percutaneous Nephrolithotomy (miniPCNL) for 2-3 cm Renal Stones

An interventional study of Retrograde Intrarenal Surgery and Mini Percutaneous Nephrolithotomy in Kidney Stones and Nephrolithiasis, sponsored by Necmettin Erbakan University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-20.

Sponsored by Necmettin Erbakan University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 3 years 7 months after the study started (first participant enrolled Jun 2022, registered Jan 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
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Study summary

This prospective cohort study aims to compare the safety and efficacy of retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath versus mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones.

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Conditions studied

  • Kidney Stones
  • Nephrolithiasis
03

In context

Kidney Calculi

597 studies on the registry are indexed under Kidney Calculi; 162 are open to participants now.

This study's enrollment of 60 is below the median of 90 across 460 interventional studies indexed under Kidney Calculi.

Browse Kidney Calculi studies →

Lead sponsor

Necmettin Erbakan University is the lead sponsor of 198 studies on the registry; 48 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age ≥18 years
  • Kidney stones measuring 2-3 cm
  • Suitable for Retrograde Intrarenal Surgery (RIRS) or Mini-Percutaneous Nephrolithotomy (MiniPCNL)
  • Provided written informed consent

Exclusion criteria

Exclusion Criteria:

  • Pregnancy
  • Renal transplantation
  • Congenital renal anomalies
  • Uncorrectable coagulopathy
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    Retrograde Intrarenal Surgery (RIRS) Group

    Intervention: Procedure-Retrograde Intrarenal Surgery

    Procedure: Retrograde Intrarenal Surgery

  • Experimental
    Mini-Percutaneous Nephrolithotomy (MiniPCNL) Group

    Intervention: Procedure- Mini Percutaneous Nephrolithotomy

    Procedure: Mini Percutaneous Nephrolithotomy

Interventions

  • ProcedureRetrograde Intrarenal Surgery

    We performed retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath in patients with 2-3 cm renal stones.

  • ProcedureMini Percutaneous Nephrolithotomy

    We performed mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones.

06

What researchers measure

Primary outcomes

  1. Stone-Free Rate

    Time frame: 1 month

Secondary outcomes

  1. Hemoglobin change

    Time frame: postoperative first day

  2. Fluoroscopy time

    Time frame: Perioperative

  3. Complications

    Time frame: up to 4 weeks

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Study locations

1 site
  • Necmettin Erbakan University Medical Faculty
    Konya, Konya, Turkey (Türkiye)
08

References and documents

Publications

  • Kilinc MT, Goger YE, Cavdar OF, Taskapu HH, Ozkent MS. Comparative outcomes of flexible ureterorenoscopy with high-power holmium: YAG laser and flexible, navigable suction access sheath vs mini-percutaneous nephrolithotomy in 2-3 cm kidney stones treatment: a prospective cohort study. BMC Urol. 2026 Jul 11. doi: 10.1186/s12894-026-02250-x. Online ahead of print. PubMed 42436463 ↗

Individual participant data

Plan to share: Yes

Supporting information: Study protocol

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07349992
Lead sponsor
Necmettin Erbakan University
Responsible party
Muzaffer Tansel Kilinc (MD, Principal Investigator, Necmettin Erbakan University) — Principal investigator
First posted
Jan 20, 2026
Start date
Jun 1, 2022
Primary completion
Jun 1, 2024
Completion
Jun 1, 2024
Last update
Jan 20, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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