An observational study in Sex Chromosome Disorders, sponsored by University of Aarhus. Enrolling by invitation at 1 site in Denmark. Open to participants aged 0 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-01-14.
Sponsored by University of Aarhus · Observational
The aim of the project is to:
125 studies on the registry are indexed under Turner Syndrome; 33 are open to participants now.
This study's planned enrollment of 300 is above the median of 164 across 70 observational studies indexed under Turner Syndrome.
Browse Turner Syndrome studies →University of Aarhus is the lead sponsor of 1,300 studies on the registry; 189 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Recruitment of cases will take place at obstetric departments, departments of clinical genetics, and pediatric departments throughout Denmark.
Recruitment of controls will take place at the Department of Gynecology and Obstetrics and Department of Pediatrics, Aarhus University Hospital as well as via Facebook groups.
Inclusion Criteria for pregnant participants in case group:
Age ≥18 years Fetus with a genetically verified sex chromosome disorder Written
Inclusion Criteria for pregnant participants in control group:
Age ≥18 years Normal first- and second-trimester ultrasound examinations Fetal growth within the normal range Written informed consent
Inclusion Criteria for mothers in the case group:
Age ≥18 years at the time of pregnancy with the child Child with a genetically verified sex chromosome disorder Written informed consent
Inclusion Criteria for mothers in the control group:
Age ≥18 years at the time of pregnancy with the child Normal first- and second-trimester ultrasound examinations during the pregnancy Normal fetal growth during the pregnancy Written informed consent
Inclusion Criteria for children in the case group:
If parents share joint custody, written informed consent must be obtained from both parents Ability to undergo a physical examination Child with a genetically verified sex chromosome disorder (prenatally or postnatally diagnosed)
Inclusion Criteria for children in the control group:
If parents share joint custody, written informed consent must be obtained from both parents Ability to undergo a physical examination
Exclusion Criteria for all groups:
Severe claustrophobia Implanted magnetic material contraindicating MRI
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Level of DNA methylation
Levels of DNA methylation in placenta, blood, saliva, and urothelial cells
Time frame: 5 years
Level of RNA ekspression
Level of RNA ekspression in placenta, blood, saliva, and urothelial cells
Time frame: 5 years
Height
Height in centimeter (cm)
Time frame: 5 years
Weight
Weight in kilogram (kg) or gram (g)
Time frame: 5 years
Body mass index
Body mass index (BMI) in kg/m²
Time frame: 5 years
Head circumference
head circumference in centimeter (cm)
Time frame: 5 years
Fat mass and fat-free mass
Measure of fat mass and fat-free mass by PEA POD (kg)
Time frame: 5 years
Development
Bayley-4 will be used to measure development. Ages \& Stages Questionnaires will be used to measure development including social-emotional development drawing on the parents knowledge.
Time frame: 5 years
Fecal microbial diversity
Measure of fecal microbial diversity
Time frame: 5 years
Fecal microbial composition
Measurement of fecal microbial composition
Time frame: 5 year
Left ventricular ejection fraction
Left ventricular ejection fraction measured by echocardiography (%)
Time frame: 5 years
Left ventricular diameters
Left ventricular end-diastolic and end-systolic diameters measured by echocardiography (mm)
Time frame: 5 years
Interventricular septal wall thickness
Interventricular septal wall thickness measured by echocardiography (mm)
Time frame: 5 years
Heart rate
Heart rate (beats per minute) measured by electrocardiogram
Time frame: 5 years
PR interval
PR interval (ms) measured by electrocardiogram
Time frame: 5 years
QRS duration
QRS duration (ms) measured by electrocardiogram
Time frame: 5 years
Corrected QT interval
Corrected QT interval (ms) measured by electrocardiogram
Time frame: 5 years
Blood pressure
Systolic and diastolic blood pressure (mmHg)
Time frame: 5 years
Congenital heart malformation
Congenital heart malformation assessed by echocardiography
Time frame: 5 years
Aorta diameter
Aorta diameter (mm) measured by echocardiography
Time frame: 5 years
Aortic valve mean gradient
Measure of aortic valve mean gradient (mmHG)
Time frame: 5 years
Mitral valve mean gradient
Measure of mitral valve mean gradient (mmHg)
Time frame: 5 years
Transaortic doppler flow
Measure of transaortic doppler flow (m/s)
Time frame: 5 years
Fetal brain volume
Fetal brain volume measured by MRI (cm³)
Time frame: 5 years
Fetal heart volume
Fetal heart volume measured by MRI (cm³)
Time frame: 5 years
Fetal kidney volume
Fetal kidney volume measured by MRI (cm³)
Time frame: 5 years
Fetal lever volume
Fetal lever volume measured by MRI (cm³)
Time frame: 5 years
Fetal spleen volume
Fetal spleen volume measured by MRI (cm³)
Time frame: 5 years
Fetal gonadal volume
Fetal gonadal volume measured by MRI (cm³)
Time frame: 5 years
Left ventricular mass
Calculation of left ventricular mass (g)
Time frame: 5 years
Plan to share: No
No publications or documents are linked to this record.
Started Sep 2024 (actual). Primary completion is estimated for Jan 2034, 112 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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